Factors Predicting Quality of Life of Patients with Acute Leukemia Undergoing Chemotherapy

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Sasiwimon Suansomran
Yaowarat Matchim
Benyaporn Baannasarn


Objective: This study aimed to determine factors predicting quality of life of patients with acute leukemia undergoing chemotherapy. Methods: The participants included 130 patients with acute leukemia undergoing chemotherapy. Data were collected from July 2018 to July 2019. The instruments used to collect the data included: 1) a demographic data form; 2) a biological function form; 3) the M.D. Anderson Symptom Inventory (MDASI)-AML/MDS include severity and interference was used to test the stability which yielded 0.82 for severity, and 0.85 for interference; 4) the Inventory of Functional Status-Cancer (IFS–CA) tested for internal consistency reliability using Cronbach’s alpha coefficients, and yielded 0.87; and 5) the Functional Assessment of Cancer Therapy-Leukemia (Version 4) tested for internal consistency reliability using Cronbach’s alpha coefficients, and yielded 0.86. Results: The multiple regression analysis with enter method revealed that all of the independent variables jointly explained 72.10% of the variance in the patient’s quality of life with a statistical significance (R2 = .721, p < .01). Discussion: The findings of this study can be used in planning for the better quality of life of patients with acute leukemia undergoing chemotherapy, especially in terms of managing symptom severity and symptom interference, as well as promoting their functional status.


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Suansomran, S., Matchim, Y., & Baannasarn, B. (2021). Factors Predicting Quality of Life of Patients with Acute Leukemia Undergoing Chemotherapy. Journal of Research in Nursing-Midwifery and Health Sciences, 41(2), 47–56. Retrieved from https://he02.tci-thaijo.org/index.php/nur-psu/article/view/247023
Research Articles


Seksan P, Prayoonwat W, Intraragumthornchai T. Evidencebased guidelines for treating hematologic diseases in Thailand. Bangkok: The Thai Society of Hematology; 2013. Thai.

Musarezaie A, Khaledi F, Esfahani H, et al. Factors affecting quality of life and fatigue in patients with leukemia under chemotherapy. J Edu Health Promot. 2014; 3: 64. doi: 10.4103/2277-9531.134778.

Kim H, Oh E, Lee H, et al. Predictors of symptom experience in Korean patients with cancer undergoing

chemotherapy. Eur J Oncol Nurs. 2015; 19(6): 644-53. doi: 10.1016/j.ejon.2015.04.003.

Petpichetchian W. Best nursing practice in cancer care. Songkla: Chanmuang Press; 2011.

Ferrans C, Zerwic J, Wilbur J, et al. Conceptual model of health-related quality of life. J Nurs Scholarsh. 2005;

(4): 336-42. doi: 10.111/j.1547-5069.2005.00058.x.

Alibhai SM, Breunis H, Timilshina N, et al. Quality of life and physical function in adults treated with intensive chemotherapy for acute myeloid leukemia improve over time independent of age. J Geriatr Oncol. 2015; 6(4): 262-71. doi: 10.1016/j.jgo.2015.04.002.

Boxer L. How to approach neutropenia. Hematology. Am Soc Hematol Educ Program. 2012; 1: 174-82. doi: 10.1182/asheducation-2012.1.174.

Lekdamrongkul P. Factor associated with febrile nuetropenia in acute leukemia patients receiving chemotherapy. [dissertation]. [Nakhonpathom]: Mahidol University; 2009. 123 p.

Temtap S, Nilmanat K. Symptom experience and management among people with acute myeloid leukaemia

in Thailand. Int J Palliat Nurs. 2011; 17(8): 381-6. doi: 10.12968/ijpn.2011.17.8.381.

Hansen B, Wendelbo Q, Bruserud Q, et al. Febrile neutropenia in acute leukemia. epidemiology, etiology,

pathophysiology and treatment. Mediterr J Hematol Infect Dis. 2020; 12(1): e2020009-e. doi: 10.4084/


Papadopoulou C, Johnston B, Themessl-Huber M. The experience of acute leukaemia in adult patients: A qualitative thematic synthesis. Eur J Oncol Nurs. 2013; 17(5): 640-8. doi: 10.1016/j.ejon.2013.06.009.

Leunis A, Redekop W, Uyl-de Groot C, et al. Impaired health-related quality of life in acute myeloid leukemia survivors: A single-center study. Eur J Haematol. 2014; 93(3): 198-206. doi: 10.1111/ejh.12324.

Kongsaktrakul P. Relationship between types of cancer, fatique experience, fatique management strateries,

family support and functional status of cancer patients receiving chemotherapy [dissertation]. [Bangkok]:

Chulalongkorn University; 2004. 170 p.

Wang C, Yan J, Chen J, et al. Factors associated with quality of life of adult patients with acute leukemia and their family caregivers in China: A cross-sectional study. Health Qual Life Outcomes. 2020; 18(1): 8. doi: 10.1186/s12955-020-1269-8.

Korol E, Wang S, Johnston K, et al. Health-Related quality of life of patients with acute myeloid leukemia:

A systematic literature review. Oncology and Therapy. 2017; 5(1): 1-16. doi: 10.1007/s40487-016-0039-6.

Ananta-ard N. Predictive factors of health-related quality of life among persons with hematological malignancy receiving chemotherapy. [dissertation]. [Bangkok]: Chulalongkorn University; 2014. 206 p.

Thorndike RM. Correlation procedures for research. New York: Gradner Press. 1978.

Stalfelt M. Quality of life during induction treatment of acute myeloid leukaemia. A comparison of three

intensive chemotherapy regimens using three instruments for quality of life assessment. Acta Oncol. 1994;

(5): 477-85. doi: 10.3109/02841869409083922.

Trotti A, Colevas AD, Setser A, et al. CTCAE v3.0: Development of a comprehensive grading system for the adverse effects of cancer treatment Semin. Radiat Oncol. 2003; 13(3): 176-81. doi: 10.1016/s1053-4296(03)00031-6.

Williams L, Ahaneku H, Cortes J, et al. Comparison of symptom burden in acute myeloid leukemia (AML)

and myelodysplastic Syndrome (MDS). Blood. 2014; 124(21): 2652-52. doi: 10.1182/blood.V124.21.2652.2652.

Tulman L, Fawcett J, McEvoy M. Development of the inventory of functional status-cancer. Cancer Nurs. 1991;

(5): 254-60.

Cella D, Jensen S, Webster K, et al. Measuring health-related quality of life in leukemia: the Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu) questionnaire. Value Health. 2012; 15(8): 1051-8. doi: 10.1016/j.jval.2012.08.2210.

Jitnumsub P. Qaulity of life in acute leukemia patients in Siriraj Hospital. [dissertation]. [Nakhonpathom]: Silpakorn University; 2009. 102 p. Thai.

Gallegos M, Borjas C, Zuniga G, et al. Pathophysiology of acute lymphoblastic leukemia. In: Mejia-Arangure

JM, editor. clinical epidemiology of acute lymphoblastic leukemia-from the molecules to the Clinic. Rijeka: InTech; 2013.

Mojtaba M, Shahram B, Monir R, et al. The relationship between pain, fatigue, sleep disorders and quality

of life in adult patients with acute leukaemia: During the first year after diagnosis. Eur J Cancer Care (Engl).

; 27(1): e12762. doi: 10.1111/ecc.12762.

Bryant A, Walton A, Shawt J, et al. Patient-reported symptoms and quality of life in adults with acute leukemia: A systematic review. Oncol Nurs Forum. 2015; 42(2): e91-e101. doi: 10.1188/15.ONF.E91-E101.

Albrecht T. Physiologic and psychological symptoms experienced by adults with acute leukemia: An

integrative literature review. Oncol Nurs Forum. 2014; 41(3): 286-95. doi: 10.1188/14.onf.286-295.