การแบ่งชนิดของมะเร็งกระเพาะอาหารแบบ Lauren’s classification ในโรงพยาบาลพระมงกุฎเกล้า

Abstract

Gastric cancer is one of the most common cancer in Thailand. The treatment is multimodality treatment  but the result remained unsatisfied. Currently Histologic classification is an important factor to determined severity and prognosis of gastric cancer especially Lauren’s classification. Objective: To study clinical feature and severity of gastric cancer with Lauren’s classification especially location staging and treatment of gastric  cancer. Methods: Descriptive study in gastric cancer between August 2001 - July 2004 in Phramongkutklao hospital. Demographic data and clinical data were collected. Histologic pathology was classified depended on Lauren’s classification into intestinal type and diffuse type. Results: Sixty eight patients with gastriccancer (44 male,24 female) were included in this study. There ages ranged from 29 to 88 years (average  57 years).Regarding Lauren’s classification it was found that 24 patients (39.7%) were intestinal type and 41 patients  (60.3%) were diffuse type. The most common symptom was dyspepsia. Most of location of cancer  was antrum. Intestinal type has found in antrum 70.4% and diffuse type has found 50.2%. Curative resection  was performed in 19 patients(72%) that found in intestinal type 45 % and diffuse type 34.5%. In diffuse type has found stage IV gastric cancer more than intestinal type (65.9 VS 44.4%) Conclusion: Lauren’s Classification  of gastric cancer was found diffuse type more than intestinal type but no significant different in demographic  data clinical feature location and treatment. But diffuse type has been stage IV more than intestinal type that mean the treatment for cure was performed unsatisfied. However further study for Lauren’s classification in Phramongkutklao hospital should be performed  in tumor recurrence and survival rate.