Neonatal Arterial Ischemic Stroke (NAIS) Neonatal Arterial Ischemic Stroke (NAIS)
Article Sidebar
Published:
Dec 30, 2021
Keywords:
neonatal arterial ischemic stroke Middle cerebral artery stroke, seizure, hemiplegia, delay development
Main Article Content
Abstract
Neonatal stroke is a rare event that occurs in term newborns. Most affected infants presented with seizures and focal neurological deficit. The prognosis from neonatal stroke is complex despite potential increased plasticity in the developing brain. The majority of the patients have complete recovery as well as the less remain residual neurodevelopmental deficit. We demonstrate a case of one-day female newborn presented with seizure and right hemiparesis from left middle cerebral artery ischemic stroke. Fortunately, her seizures were controlled during the perinatal period, with no later epilepsy. In term of the developmental outcome, she had global developmental delay initially and underwent intensive regular early intervention for 2 years. At 3 years of age, she has significant improvement in all developmental domains except mild delay expressive language. This case supports the evidence of good outcomes in neonatal stroke despite the large lesion.
Article Details
Section
รายงานผู้ป่วย (Case Report)
References
เอกสารอ้างอิง
1. Lynch JK, Nelson KB. Epidemiology of perinatal stroke. Curr Opin Pediatr. 2001;13(6):499-505.
2. Chabrier S, Husson B, Dinomais M, Landrieu P, Nguyen The Tich S. New insights (and new interrogations) in perinatal arterial ischemic stroke. Thromb Res. 2011;127(1):13-22.
3. Wu YW, Lynch JK, Nelson KB. Perinatal arterial stroke: understanding mechanisms and outcomes. Semin Neurol. 2005;25(4):424-34.
4. Ciccone S, Cappella M, Borgna-Pignatti C. Ischemic stroke in infants and children: practical management in emergency. Stroke Res Treat. ;2011:736965.
5. Kirton A, Deveber G. Life after perinatal stroke. Stroke. 2013;44(11):3265-71.
6. Nudo RJ. Neural bases of recovery after brain injury. J Commun Disord. 2011;44(5):515-20.
7. Kolb B, Teskey GC. Age, experience, injury, and the changing brain. Dev Psychobiol. 2012;54(3):311-25.
8. Golomb MR, deVeber GA, MacGregor DL, Domi T, Whyte H, Stephens D, et al. Independent walking after neonatal arterial ischemic stroke and sinovenous thrombosis. J Child Neurol. 2003;18(8):530-6.
9. Grunt S, Mazenauer L, Buerki SE, Boltshauser E, Mori AC, Datta AN, et al. Incidence and outcomes of symptomatic neonatal arterial ischemic stroke. Pediatrics. 2015;135(5):e1220-8.
10. Sreenan C, Bhargava R, Robertson CM. Cerebral infarction in the term newborn: clinical presentation and long-term outcome. J Pediatr. 2000;137(3):351-5.
11. Lee J, Croen LA, Lindan C, Nash KB, Yoshida CK, Ferriero DM, et al. Predictors of outcome in perinatal arterial stroke: a population-based study. Ann Neurol. 2005;58(2):303-8.
12. Mercuri E, Barnett A, Rutherford M, Guzzetta A, Haataja L, Cioni G, et al. Neonatal cerebral infarction and neuromotor outcome at school age. Pediatrics. 2004;113(1 Pt 1):95-100.
13. Nelson KB, Lynch JK. Stroke in newborn infants. Lancet Neurol. 2004;3(3):150-8.
14. Kirton A. Modeling developmental plasticity after perinatal stroke: defining central therapeutic targets in cerebral palsy. Pediatr Neurol. 2013;48(2):81-94.
15. Sakzewski L, Ziviani J, Boyd R. Systematic review and meta-analysis of therapeutic management of upper-limb dysfunction in children with congenital hemiplegia. Pediatrics. 2009;123(6):e1111-22.
16. Ricci D, Mercuri E, Barnett A, Rathbone R, Cota F, Haataja L, et al. Cognitive outcome at early school age in term-born children with perinatally acquired middle cerebral artery territory infarction. Stroke. 2008;39(2):403-10.
17. McLinden A, Baird AD, Westmacott R, Anderson PE, deVeber G. Early cognitive outcome after neonatal stroke. J Child Neurol. 2007;22(9):1111-6.
18. Muter V, Taylor S, Vargha-Khadem F. A longitudinal study of early intellectual development in hemiplegic children. Neuropsychologia. 1997;35(3):289-98.
19. Ballantyne AO, Spilkin AM, Hesselink J, Trauner DA. Plasticity in the developing brain: intellectual, language and academic functions in children with ischaemic perinatal stroke. Brain. 2008;131(Pt 11):2975-85.
20. Westmacott R, MacGregor D, Askalan R, deVeber G. Late emergence of cognitive deficits after unilateral neonatal stroke. Stroke. 2009;40(6):2012-9.
21. Levine SC, Kraus R, Alexander E, Suriyakham LW, Huttenlocher PR. IQ decline following early unilateral brain injury: a longitudinal study. Brain Cogn. 2005;59(2):114-23.
22. Armstrong-Wells J, Ferriero DM. Diagnosis and acute management of perinatal arterial ischemic stroke. Neurol Clin Pract. 2014;4(5):378-85.
23. Chilosi AM, Cipriani P, Pecini C, Brizzolara D, Biagi L, Montanaro D, et al. Acquired focal brain lesions in childhood: effects on development and reorganization of language. Brain Lang. 2008;106(3):211-25.
24. Reilly JS, Wasserman S, Appelbaum M. Later language development in narratives in children with perinatal stroke. Dev Sci. 2013;16(1):67-83.
25. Liégeois F, Connelly A, Cross JH, Boyd SG, Gadian DG, Vargha-Khadem F, et al. Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study. Brain. 2004;127(Pt 6):1229-36.
26. van Dongen HR, Paquier PF, Creten WL, van Borsel J, Catsman-Berrevoets CE. Clinical evaluation of conversational speech fluency in the acute phase of acquired childhood aphasia: does a fluency/nonfluency dichotomy exist? J Child Neurol. 2001;16(5):345-51.
27. Paquier PF, Van Dongen HR. Review of research on the clinical presentation of acquired childhood aphasia. Acta Neurol Scand. 1996;93(6):428-36.
28. Raja Beharelle A, Dick AS, Josse G, Solodkin A, Huttenlocher PR, Levine SC, et al. Left hemisphere regions are critical for language in the face of early left focal brain injury. Brain : a journal of neurology. 2010;133(Pt 6):1707-16.
29. Guzzetta A, Pecini C, Biagi L, Tosetti M, Brizzolara D, Chilosi A, et al. Language organisation in left perinatal stroke. Neuropediatrics. 2008;39(3):157-63.
30. Rapin I. Acquired aphasia in children. J Child Neurol. 1995;10(4):267-70.
1. Lynch JK, Nelson KB. Epidemiology of perinatal stroke. Curr Opin Pediatr. 2001;13(6):499-505.
2. Chabrier S, Husson B, Dinomais M, Landrieu P, Nguyen The Tich S. New insights (and new interrogations) in perinatal arterial ischemic stroke. Thromb Res. 2011;127(1):13-22.
3. Wu YW, Lynch JK, Nelson KB. Perinatal arterial stroke: understanding mechanisms and outcomes. Semin Neurol. 2005;25(4):424-34.
4. Ciccone S, Cappella M, Borgna-Pignatti C. Ischemic stroke in infants and children: practical management in emergency. Stroke Res Treat. ;2011:736965.
5. Kirton A, Deveber G. Life after perinatal stroke. Stroke. 2013;44(11):3265-71.
6. Nudo RJ. Neural bases of recovery after brain injury. J Commun Disord. 2011;44(5):515-20.
7. Kolb B, Teskey GC. Age, experience, injury, and the changing brain. Dev Psychobiol. 2012;54(3):311-25.
8. Golomb MR, deVeber GA, MacGregor DL, Domi T, Whyte H, Stephens D, et al. Independent walking after neonatal arterial ischemic stroke and sinovenous thrombosis. J Child Neurol. 2003;18(8):530-6.
9. Grunt S, Mazenauer L, Buerki SE, Boltshauser E, Mori AC, Datta AN, et al. Incidence and outcomes of symptomatic neonatal arterial ischemic stroke. Pediatrics. 2015;135(5):e1220-8.
10. Sreenan C, Bhargava R, Robertson CM. Cerebral infarction in the term newborn: clinical presentation and long-term outcome. J Pediatr. 2000;137(3):351-5.
11. Lee J, Croen LA, Lindan C, Nash KB, Yoshida CK, Ferriero DM, et al. Predictors of outcome in perinatal arterial stroke: a population-based study. Ann Neurol. 2005;58(2):303-8.
12. Mercuri E, Barnett A, Rutherford M, Guzzetta A, Haataja L, Cioni G, et al. Neonatal cerebral infarction and neuromotor outcome at school age. Pediatrics. 2004;113(1 Pt 1):95-100.
13. Nelson KB, Lynch JK. Stroke in newborn infants. Lancet Neurol. 2004;3(3):150-8.
14. Kirton A. Modeling developmental plasticity after perinatal stroke: defining central therapeutic targets in cerebral palsy. Pediatr Neurol. 2013;48(2):81-94.
15. Sakzewski L, Ziviani J, Boyd R. Systematic review and meta-analysis of therapeutic management of upper-limb dysfunction in children with congenital hemiplegia. Pediatrics. 2009;123(6):e1111-22.
16. Ricci D, Mercuri E, Barnett A, Rathbone R, Cota F, Haataja L, et al. Cognitive outcome at early school age in term-born children with perinatally acquired middle cerebral artery territory infarction. Stroke. 2008;39(2):403-10.
17. McLinden A, Baird AD, Westmacott R, Anderson PE, deVeber G. Early cognitive outcome after neonatal stroke. J Child Neurol. 2007;22(9):1111-6.
18. Muter V, Taylor S, Vargha-Khadem F. A longitudinal study of early intellectual development in hemiplegic children. Neuropsychologia. 1997;35(3):289-98.
19. Ballantyne AO, Spilkin AM, Hesselink J, Trauner DA. Plasticity in the developing brain: intellectual, language and academic functions in children with ischaemic perinatal stroke. Brain. 2008;131(Pt 11):2975-85.
20. Westmacott R, MacGregor D, Askalan R, deVeber G. Late emergence of cognitive deficits after unilateral neonatal stroke. Stroke. 2009;40(6):2012-9.
21. Levine SC, Kraus R, Alexander E, Suriyakham LW, Huttenlocher PR. IQ decline following early unilateral brain injury: a longitudinal study. Brain Cogn. 2005;59(2):114-23.
22. Armstrong-Wells J, Ferriero DM. Diagnosis and acute management of perinatal arterial ischemic stroke. Neurol Clin Pract. 2014;4(5):378-85.
23. Chilosi AM, Cipriani P, Pecini C, Brizzolara D, Biagi L, Montanaro D, et al. Acquired focal brain lesions in childhood: effects on development and reorganization of language. Brain Lang. 2008;106(3):211-25.
24. Reilly JS, Wasserman S, Appelbaum M. Later language development in narratives in children with perinatal stroke. Dev Sci. 2013;16(1):67-83.
25. Liégeois F, Connelly A, Cross JH, Boyd SG, Gadian DG, Vargha-Khadem F, et al. Language reorganization in children with early-onset lesions of the left hemisphere: an fMRI study. Brain. 2004;127(Pt 6):1229-36.
26. van Dongen HR, Paquier PF, Creten WL, van Borsel J, Catsman-Berrevoets CE. Clinical evaluation of conversational speech fluency in the acute phase of acquired childhood aphasia: does a fluency/nonfluency dichotomy exist? J Child Neurol. 2001;16(5):345-51.
27. Paquier PF, Van Dongen HR. Review of research on the clinical presentation of acquired childhood aphasia. Acta Neurol Scand. 1996;93(6):428-36.
28. Raja Beharelle A, Dick AS, Josse G, Solodkin A, Huttenlocher PR, Levine SC, et al. Left hemisphere regions are critical for language in the face of early left focal brain injury. Brain : a journal of neurology. 2010;133(Pt 6):1707-16.
29. Guzzetta A, Pecini C, Biagi L, Tosetti M, Brizzolara D, Chilosi A, et al. Language organisation in left perinatal stroke. Neuropediatrics. 2008;39(3):157-63.
30. Rapin I. Acquired aphasia in children. J Child Neurol. 1995;10(4):267-70.