An extremely rare presentation of hybrid schwannoma/neuroma

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ระพีพัฒน์ ทรัพย์รวงทอง


Hybrid peripheral nerve sheath tumor(HPNST) is benign peripheral nerve sheath tumor which present as a soft tissue mass with or without neurologic symptoms. HPNST shows combination of more than one type of peripheral nerve sheath tumors such as schwannoma/perineurioma, neurofibroma/schawannoma and neurifibroma/perineurioma. HPNST is rare disease that may be idiopathic or may occur in association with neurofibromatosis and schwannomatosis. HPNST have not been reported malignant transformation.

         In this report, we present a case of HPNST that involve brachial plexus and never been reported in the previous literature.

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รายงานผู้ป่วย (Case Report)


1. Alomair A, Dababo M, Velagapudi S. Supraclavicular Solitary Hybrid Schwannoma/Neurofibroma: A Case Report. Cureus. 2020;12(6):e8531.
2. Ud Din N, Ahmad Z, Abdul-Ghafar J, Ahmed R. Hybrid peripheral nerve sheath tumors: report of five cases and detailed review of literature. BMC Cancer. 2017;17(1):349.
3. Hornick JL, Bundock EA, Fletcher CD. Hybrid schwannoma/perineurioma: clinicopathologic analysis of 42 distinctive benign nerve sheath tumors. Am J Surg Pathol. 2009;33(10):1554-61.
4. Murărescu ED, Ivan L, Mihailovici MS. Neurofibroma, schwannoma or a hybrid tumor of the peripheral nerve sheath? Rom J Morphol Embryol. 2005;46(2):113-6.
5. Rodriguez FJ, Folpe AL, Giannini C, Perry A. Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems. Acta Neuropathol. 2012;123(3):295-319.
6. Youens KE, Woodward J, Wallace D, Cummings TJ. Hybrid neurofibroma-schwannoma of the orbit. Orbit. 2008;27(3):223-5.
7. Panda KM, Reena N. Intraneural Hybrid Neurofibroma/Schwannoma In Scalp: A Case Report. J Clin Diagn Res. 2015;9(10):ED05-6.
8. Hussain NS, Specht CS, Frauenhoffer E, Glantz M, Harbaugh K. Hybrid Neurofibroma-Schwannoma. Cureus. 2016;8(3):e548.
9. Shanouda S, Kaya G. Benign Cutaneous Peripheral Nerve Sheath Tumor with Hybrid Features: Report of Two Cases with Schwannoma/Perineurioma and Schwannoma/Neurofibroma Components. Dermatopathology (Basel). 2017;4(1-4):1-6.
10. Taubenslag KJ, Nickols HH, Chelnis JG, Mawn LA. Hybrid Neurofibroma/Schwannoma of the Supraorbital Nerve: Clinicopathologic Correlation of a Rare Tumor. Ophthalmic Plast Reconstr Surg. 2017;33(3S Suppl 1):S104-S6.