The Comparison of Intraocular Pressure between the Treatment for Osteoarthritis in Aging Patients with Glucosamine Sulfate and without Glucosamine Sulfate Intraocular Pressure after Glucosamine Intake

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Isaraporn Treesit
Piyawadee Nimitchotinai
Raveewan Choontanom
Wallop Iemsomboon
Panrapee Funarunart


Background: Glucosamine is widely prescribed for osteoarthritis (OA) treatment because of its effectiveness and safety profile. However, there was a study reported about glucosamine associated with the increase of intraocular pressure (IOP) in patients with glaucoma. The effect of IOP elevation in non-glaucomatous population is still inconclusive.

Purpose: To compare the change of IOP between the treatment for osteoarthritis with and without glucosamine sulfate in aging patients.

Methods: This is a prospective comparative study. OA patients were enrolled and divided into two groups depending on the indications for glucosamine sulfate treatment. Twenty patients were treated with oral glucosamine sulfate and twenty patients were treated with other medications. IOP was measured before glucosamine sulfate treatment, 2, 4, 8, 12, 24 weeks after glucosamine sulfate treatment, and 2 weeks after stopping glucosamine sulfate treatment. The change of IOP was compared between the two groups. Statistical analysis used 2-way repeated-measures analysis of variance with a 2-tailed t-test.

Results: Forty patients were identified and met inclusion criteria. The mean age was 67.24+8.45 years. There was no difference in patients' characteristics between groups except age which the glucosamine group was younger (63.33 vs 70.75, p=0.005). In the glucosamine group (n=20), baseline IOP was 13.96±1.82 mmHg. IOP increased significantly from baseline in 2 weeks after starting glucosamine supplementation (+0.93±1.21 mmHg, p=0.005). There was no statistical change of IOP compared to baseline in other visits including the visit after glucosamine withdrawal. In the non-glucosamine group, baseline IOP was 14.16±2.57 mmHg. There was no change of IOP in any visit.

Conclusion: IOP was significantly increased at 2 weeks after taking glucosamine sulfate. There was no statistical change of IOP compared to baseline in other visits including the visit after glucosamine withdrawal.

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นิพนธ์ต้นฉบับ (Original Article)


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