The study of time duration used for diagnosis in the patient with mycosis fungoides: a retrospective study
Main Article Content
Abstract
Abstract
Background
An earlier diagnosis of mycosis fungoides correlates with a better prognosis of the patients. Unfortunately, it’s difficult to early diagnosis because the clinical manifestations are not specific and skin biopsies do not always suggest a definite diagnosis
Objective
The study aimed to determine the median duration from the onset of the disease symptoms to the time of diagnosis among patients with mycosis fungoides.
Material and methods
A retrospective study included patients who received a diagnosis of mycosis fungoides at Phramongkutklao Hospital from 2010 to 2020
Results
The median time needed to diagnose mycosis fungoides was 14 months (interquartile range; 5-48 months). Twelve patients (44.4%) could not confirm the diagnosis of mycosis fungoides in the first attempted skin biopsy. The mean accumulation number of skin biopsies needed to diagnose mycosis fungoides was 2.6 + 1.9 samples. When we compared the patients with early diagnosis (within 12 months) with late diagnosed patients, no difference was found in age, sex and clinical presentation.
Conclusions
The median time to diagnose mycosis fungoides was as long as 14 months. Multiple skin biopsy samples are strongly recommended to improve the diagnostic yield.
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
References
Reference
Keto J, Hahtola S, Linna M, Väkevä L. Mycosis fungoides and Sézary syndrome: a population-wide study on prevalence and health care use in Finland in 1998-2016. BMC Health Serv Res. 2021 Feb 22;21(1):166.
Zackheim HS, Amin S, Kashani-Sabet M, McMillan A. Prognosis in cutaneous T-cell lymphoma by skin stage: long-term survival in 489 patients. J Am Acad Dermatol. 1999 Mar;40(3):418-25.
Wilcox RA. Cutaneous T-cell lymphoma: 2017 update on diagnosis, risk-stratification, and management. Am J Hematol. 2017 Oct;92(10):1085-1102.
Kim YH, Liu HL, Mraz-Gernhard S, Varghese A, Hoppe RT. Long- term outcome of 525 patients with mycosis fungoides and Sezary syndrome: clinical prognostic factors and risk for disease progres- sion. Arch Dermatol. 2003;139:857–866.
Van Doorn R, Van Haselen CW, van Voorst Vader PC, et al. Myco- sis fungoides: disease evolution and prognosis of 309 Dutch patients. Arch Dermatol. 2000;136:504–510.
Arulogun SO, Prince HM, Ng J, et al. Long-term outcomes of patients with advanced-stage cutaneous T-cell lymphoma and large cell transformation. Blood. 2008;112:3082–3087.