Effects of Tibolone in Thai Post-menopausal Women

Abstract

Objective To assess the effects of tibolone on climacteric symptoms, serum levels of sex hormones (FSH, LH, Ea), lipids and calcium as well as the bone mineral density in Thai Post-menoPausal women'

Main outcome measures Climacteric symptoms were assessed periodically. Serum levels of sex hormones, lipids and calcium as well as the bone mineral density were measured at the beginning and the end of the study.

Results Climacteric symptoms decreased over the study period. There was no significant change in the levels of sex hormones, total cholesterol, apolipoprotein A and B. A reduction in the levels of HDL and calcium was observed. Bone mineral density remained unchanged.

Conclusion Tibolone is suitable for the treatment of climacteric complaint and also potentially capable to prevent post-menopausal bone loss.