Factors associated with depression and assessment of medication adherence in hemodialysis patients
Keywords:
Hemodialysis, depression, medication adherenceAbstract
The objective of this study was to explore the factors associated with depression and the prevalence of medication adherence problems among hemodialysis patients. A cross-sectional observational design was employed, and the study included patients receiving kidney replacement therapy via dialysis machines at the Dialysis Center, Thammasat University Hospital. Data on depression were collected using a self-report screening/assessment tool, while medication adherence was assessed using the Medication Adherence Scale for Thai people. Logistic regression analysis was used to examine the relationship between depression and various potential contributing factors.
A total of 85 eligible and consenting patients participated in the study, of whom 36 were female (42.4%). Among the participants, 12 patients (14.12%) were found to have depression. Female patients were 5.57 times more likely to experience depression compared to male patients (OR 5.57, 95% CI 1.24–25.11, p = 0.03). Additionally, each additional year of dialysis vintage was associated with a 20% increase in the likelihood of depression (OR 1.20, 95% CI 1.02–1.41, p = 0.03), after controlling for other variables. No significant associations were found between depression and other examined factors. Regarding medication adherence, only one patient (1.2%) reported problems with medication compliance.
In summary, gender and duration of dialysis were found to be significantly associated with the occurrence of depression in patients with end-stage kidney disease undergoing hemodialysis. However, it is important to acknowledge the limitations of this study, including the small sample size and the fact that it was conducted at a single university hospital. Therefore, caution should be exercised when generalizing these findings to broader populations.
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