Association between co-morbidities with recurrent stroke in Sikhio District, Nakhon Ratchasima Province

Abstract

This matched case-control study aimed to examine the association between comorbidities and stroke recurrence in Sikhio District, Nakhon Ratchasima Province. The sample was matched based on gender and age, with a case-to-control ratio of 1:2. A total of 111 participants were included, consisting of 37 patients with recurrent stroke (case group) and 74 patients with a single stroke episode (control group). The study was conducted from October 1, 2021, to September 30, 2022. All patients were diagnosed by a physician, received treatment at Sikhio Hospital, and had their diagnoses confirmed through computerized tomography (CT) scans. Data were collected using a structured case record form based on hospital medical records. Conditional logistic regression was employed to identify comorbidities associated with stroke recurrence, with results presented as odds ratios (ORs), 95% confidence intervals (CIs), and p-values.
The results showed that significant comorbidities associated with stroke recurrence (p < 0.05) included hypertension (OR = 2.92, 95% CI = 1.13–7.51, p = 0.019), high cholesterol (OR = 2.29, 95% CI = 1.10–5.23, p = 0.048), and heart disease (OR = 4.82, 95% CI = 1.35–17.29, p = 0.012).
In conclusion, public health efforts should focus on preventing stroke recurrence, particularly among patients with comorbid conditions such as hypertension, high cholesterol, and heart disease. Regular medical follow-up, adherence to prescribed medications, and the promotion of healthy behaviors-such as avoiding smoking and alcohol consumption-are essential to reducing the risk of recurrence.