The Effects of Oral Zinc on The Level Changes of Total Testosterone and Estradiol among Fat Male who Having Body Mass Index more than 30 kg/m2

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Suthasinee Vudtakanok


Objective: To examine the effect of Chelated Zinc on the changes in Total Testosterone, Estradiol (Estradiol / Total Testosterone Ratio).

Methods: This was a experimental, prospective, randomize, double blinded, placebo-controlled among 45 soldiers of 5th Antiaircraft Artillery Battalion, 1st Antiaircraft Artillery Regiment who were more than 40 years old and had BMI more than 30 kg/m2. This research spent 12 weeks. This experimental group obtained Chelated Zinc 15 mg/tablet, and they ate 4 tablets every morning. 

Results: The experimental results showed that most of experimental group were 50-59 years old (58.3%), followed by those aged 40-49 years old (25.0%). They had underlying diseases, such as hypertension (66.7%), followed by gout (33.3%). There were 33.3% of experimental group who had people in their families had underlying diseases and the drug use history. Most of them took medicines for the hypertension treatment and uricosuria drugs (40.0%). Most of the control group were 50-59 years old. They were as same as the experimental group (58.3%), next, they were 40-49 years old (41.1%). Most of them hadn’t any underlying diseases (66.7%) and 8.3% of them took medicines and Chelated Zinc which had the effect to BMI with the statistical significance (P<0.001).

Conclusion: The findings would be beneficial as another way to protect and decrease the risk of cardiovascular disease among men who in the risk (over 40 years old and fat). For the next experiment, the researcher would study the relative factors and the side effects of Chelated Zinc taking in people who were in the risk of cardiovascular disease for being the information about the quantity defining of the Chelated Zinc taking of each individual suitably and the risk would be decreased.

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Vudtakanok, S. (2020). The Effects of Oral Zinc on The Level Changes of Total Testosterone and Estradiol among Fat Male who Having Body Mass Index more than 30 kg/m2. Vajira Nursing Journal, 22(2), 30–39. Retrieved from
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กรมควบคุมโรค กระทรวงสาธารณสุข. (2560). ชุดรูปแบบบริการในการป้องกัน ควบคุมโรคหลอดเลือดหัวใจ โรคหลอดเลือดสมอง และโรคไตเรื้อรัง สำหรับสถานบริการ. พิมพ์ครั้งที่ 1 มีนาคม 2560. สำนักพิมพ์กิจการโรงพิมพ์ องค์การสงเคราะห์ทหารผ่านศึก ในพระบรราชูปถัมภ์.

หะทัย เทพพิสัย. (2552). โรคอ้วนลงพุง. กรุงเทพมหานคร สำนักพิมพ์กรุงเทพเวชสาร, 2552.

Ananda S.prasad. (1996). Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease. REVIEWS FROM ASN EB 2012 SYMPOSIA. American Society for Nutrition. Adv. Nutr. 4: 176–190, 2013

Debjit Bhowmik, Chiranjib, K.P. Sampath Kumar. (2010). A potential medicinal importance of zinc in human health and chronic disease. Int J Pharm Biomed Sci 2010, 1(1), 05-11.

Drug Safetyand Availability. (2014). FDA evaluating risk of stroke, heart attack and death with FDA-approved testosterone products. เข้าถึงเมื่อ ธันวาคม 22, 2061, จาก;

General Public, Healthcare Professionals, Hospitals. (2014). Information Update – Possible cardiovascular problems associated with testosterone products. เข้าถึงเมื่อ มกราคม 10, 2561, สืบค้นจาก

Jerzy K. Wranicz (2005). The relationship between sex hormones and lipid profile in men with coronary artery disease. International journal cardiology. Volume 101, Issue 1, Pages 105–110.

J.W.G. Yarnell et. Al. (1993). Employment Status and Risk Factors for Ischaemic Heart Disease:The Caerphilly Study. Journal of the Royal Statistical Society Series D 39(4):385.

K Koehler. (2007). Antigen-specific human antibodies from mice comprising four distinct genetic modifications. Nature International journal of science. April 2007, 856-859.

Kuehn BM. (2014). Cardiovascular risks of testosterone. JAMA 2014; 311 (12):1192. doi:10.1001/jama.2014.2602.

L.R. BRILLA AND VICTOR CONTE. (2000). Effects of a Novel Zinc-Magnesium Formulation on Hormones and Strength. JEPonline, 3(4): 26-36, 2000.

Marie Juul Ornstrup. (2015). Low testosterone as a better predictor of mortality than sarcopenia in men with advanced liver disease. Journal of Gastroenterdogy and Hepatology. Volume 31 Issue 3, September 2015.(1999) 6, 315-324.

Prasad AS, Abbasi AA, Rabbani P, DuMouchelle E. (1981). Effect of zinc supplementation on serum testosterone level in adult male sickle cell anemia subjects. Am J Hematol. 1981;10(2): 119-27.

Punset, K., Klinthuesin, S., Kingkaew, A., & Wongmeneeroj, W. (2015). Cardiovascular risk among staff working at the central of Ministry of public health using risk assessment of Rama-EGAT heart score. Nursing Journal of The Ministry of Public Health, 27(2), 57-70.

Stefania Frassinetti. (2006). The Role of Zinc in Life: A Review. Journal of Environmental Pathology, Toxicology and Oncology. Volume 25, 2006 Issue 3.