Utilization of Amlodipine Drug in Hypertensive Patients Reduces Stroke Outcomes at Srithep Hospital, Petchabun Province

Abstract

Background: Stroke is a major public health problem in hypertensive patients. This research aimed to study the effect of the use of Amlodipine on the occurrence of Stroke in hypertensive patients who were treated at Srithep hospital, Phetchaboon province. Method: This analytic research was case control study in hypertensive patients. The sample consisted of 121 cases of stroke and 484 cases of non-stroke hypertensive patients, that overall of subjects was 605 cases. Data were collected by studying the data from the medical records according to the criteria set during July to December 2018. Data were analyzed using statistics, percentage, mean, standard deviation, Chi-square test, Odd ratio (OR), 95%, CI and Multiple binary logistic. Significant level was indicated at 0.05. Results: The results revealed that patients with hypertension, stroke and non-stroke ratio was 1: 4. Comparison general characteristics between 2 groups including gender, age, smoking and alcohol consumption were not difference (p>0.05). Hypertensive drugs Treatment to control blood pressure founded that, the patients were treated with the most of ACE Inhibitor drug, followed by the Dyslipidemic drug and Calcium Channel blocker (Amlodipine), these were 49.6%, 36.4% and 33.7%, respectively. Interestingly, Amlodipine was factors related to stroke outcomes with 81.0% reducing the chance of stroke occur (Adj OR = 0.19, CI = 0.039-0.917, p = 0.039). While, ACE Inhibitor reduces the chance of stroke by 75.6 % (Adj OR = 0.244, CI = 0.066-0. 899, p = 0.034). Moreover, Anticoagulant drugs correlate with the occurrence of prevention of stroke by 100% (Adjusted OR = 0, CI = 0.0001-787.6, p = 0.002). However, Simvastatin was also associated with increasing the likelihood of stroke by 3155.8 time (Adj OR = 0.19, CI = 0.039-0.917, p = 0.039). Conclusion: Blood pressure control drugs in hypertensive patients that associated with reducing the likelihood of stroke outcomes were Amlodipine and ACE Inhibitor. This should therefore be consider to using for control blood pressure and also reducing the chance of stroke outcomes in hypertensive patients.