Risk Factors of Neonatal Death in Meconium Aspiration Syndrome at Trang Hospital


  • Nopawan Treeratanapaiboon , M.D. Department of Pediatrics, Trang Hospital Thap thiang


Meconium Aspiration Syndrome, Meconium stained amniotic fluid, non vigorous neonate


Background:  Meconium aspiration syndrome       ( MAS ) is an important cause of  acute respiratory distress in newborn , which has serious complication and high mortality rate. Objectives: To determine the incidence , outcome and complications of infants with MAS and prognostic factors of this conditions at Trang Hospital. Methods: This study was a retrospective descriptive study. Medical records of infants who diagnosed with MAS at Trang hospital  between  1st October 2016 and 30nd September 2019 were reviewed. Data on maternal and neonatal demographics , clinical course  and outcome were recorded. Results:  Meconium stained amniotic fluid (MSAF) was found in 556  neonates. Two hundred three neonates   of  MAS cases  were  enrolled , (36.5% of MSAF) , one hundred and fifty-nine newborn was born at Trang Hospital The incidence of MAS was 14.76 per 1000 live birth. Fifteen cases of MAS died ( mortality 7.4%) and  38.9% of MAS needed mechanical ventilation. The most common cause of death was persistent pulmonary hypertension of newborn (PPHN, 100 % ).  Other cause was sepsis ( 87.6%). The significant poor prognostic factor of MAS  were non vigorous neonate , APGAR score at 1 min and at 5 min < 3 , on mechanical ventilation , MAS with complication : PPHN , sepsis , birth asphyxia , pneumothorax and pulmonary hemorrhage. Conclusions:  Incidence of MAS during this period at Trang Hospital was 14.76  per 1000 live birth. The mortality rate was 7.4%. Poor prognostic factor was non vigorous neonate, severe birth asphyxia , on mechanical ventilation , PPHN , sepsis , pneumothorax  and pulmonary hemorrhage  The most common cause of death was PPHN.


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How to Cite

Treeratanapaiboon N. Risk Factors of Neonatal Death in Meconium Aspiration Syndrome at Trang Hospital. j dept med ser [Internet]. 2022 Jun. 29 [cited 2022 Oct. 1];47(2):45-52. Available from: https://he02.tci-thaijo.org/index.php/JDMS/article/view/250467



Original Article