Comparative Study of Transepidermal Water Loss and Skin Hydration between Conventional Cream Base and New Developed Cream Base
Keywords:
transepidermal water loss (TEWL), skin hydration, moisturizersAbstract
Background: Moisturizers are topical products designed to improve and maintain skin barrier function and to help prevent dry skin. Newly developed moisturizers were formulated by pharmaceutical production unit of Institute of Dermatology in order to get better qualifications than currently used and commercial moisturizers. Objective: To determine the effects of the newly developed formulas of moisturizers on transepidermal water loss (TEWL) and skin hydration compared to the currently used hospital formulas and the commercially available moisturizers. Method: An experimental study in 75 healthy skin volunteers was performed. The transepidermal water loss and skin hydration were determined before and after a single application of the tested cream at 1, 2 and 24 hours. Data were analyzed by descriptive statistics, repeated ANOVA. Results: After 1-2 h of a single application, the measured skin hydration of 3 newly developed cream bases were significantly greater than that of the currently used cream base (P<0.05). TEWL measured for the two newly developed formulae of cream base were also found to significantly less than that measured for the currently used formula (p<0.05). Same as the newly developed urea cream, skin hydration was significantly greater than the commercial formula (p<0.05) and TEWL was significantly less than the commercial formula (p<0.05). Skin hydration measured after applying the newly developed cold cream was significantly less than that measured for the currently used formula (p<0.05). TEWL measured for the newly developed cold cream was also found to significantly more than that measured for the currently used formula (p<0.05). Conclusion: The 3 newly developed cream bases are more effective than the currently used formula. Moreover, it was found that the newly urea cream using the developed cream base showed highly skin hydration compare to the commercial one.
References
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