Unexpected Antibodies in Cancer Patients at Maha Vajiralongkorn Thanyaburi Hospital
Keywords:
Unexpected antibodies, Cancer, Blood componentAbstract
Background : Unexpected antibodies are antibodies beyond the blood type ABO that are clinically important and cause reactions after receiving the blood components. Most cancer patients experience anemia caused by chemotherapy, radiation or from cancer. Therefore, unexpected antibodies are the problem for monitoring the cause of transfusion reactions.Objective : To study 1) prevalence of types of unexpected antibodies in cancer patients receiving blood components. 2) unexpected antibodies related to with antibody types in cancer patients requesting blood components at Maha Vajiralongkorn Thanyaburi Hospital.Method : This retrospective study based on data from cancer patients who received blood components from Maha Vajiralongkorn Thanyaburi Hospital.Result : Total of 2,516 patients, the results showed that 95 patients with unexpected antibodies (3.77%), colon cancer associated with Auto anti-I, lung cancer associated with Anti-C, Anti-e and Anti-Leb (p-value <0.05). The relation of antibody types showed Anti-C with Anti-e, Anti-c with Anti-E, Anti-E with Anti-S, Anti-Dia with Anti-Fyb, Anti-Lea with Anti-Fyb, Anti-Lea with Anti-Leb (p-value <0.01) and Anti-E with Anti-P1, Anti-P1 with Anti-Fya (p-value <0.05).Conclusion : The relationship between unexpected antibodies and type of cancer will be useful in the surveillance reaction after blood transfusion of patients with further cancer.
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