Effect of Different dose of Botulinum Toxin Injection for Lower Limb Spasticity in Cerebral Palsy Children: A Systematic Review

Abstract

Background: Cerebral palsy is a common disease in pediatric patients. Most patients have spasticity, which leads to problems with movement, standing, walking, and contracture of tendons and joints. There are several treatment choices such as stretching exercise, orthotic device, oral medication, injections and orthopedic surgery. However, the treatment effect of Botulinum toxin injection depends on many factors, for instance, the patient condition, dosage and injection method.Objective: This study aimed to review the effect of Botilinum toxin dosage in children with cerebral dosage palsy with systematic review.Methods: Searching through electronic databases. Based on a search strategy from the MEDLINE database through PubMed, educational materials were limited to Englishlanguage studies. Randomized controlled trial study: A randomized controlled trial of botulinum toxin in children with cerebral palsy with systematic review. Data collection and analysis, the risk of bias were assessed by three researchers independently, use unanimous resolution to evaluate and select the study. If there was a conflict, a joint consideration was needed to conclude.Results: The total number of studies was 40 studies. The excluded number was 36 studies. These were not related to the effect of the dosage of botulinum toxin and the measurement of non-related cerebral palsy. Remain all the results four included studies. The subjects were patients with cerebral palsy who had treated spasticity in the affected leg with botulinum toxin in different doses. The outcome measurements of the included studies were various. Patients who received higher dose had better improvement. The adverse effects were not significantly different.Conclusion: This systematic review revealed a small number of studies. To clinically useful, a comparative study should be conducted in the cerebral palsy children with other conditions, or other types of study might be included.