A Systematic Review on the Effectiveness of Topical Calcineurin Inhibitors in Vitiligo


  • Piyanuch Samtip, Pharm.D. Southern Regional Hospital of Tropical Dermatology
  • Buaphet Sriphet, B.Sc. Southern Regional Hospital of Tropical Dermatology
  • Kitipan Khaonim, M.Sc. Southern Regional Hospital of Tropical Dermatology


Topical calcineurin inhibitors, Vitiligo, Systematic review


Background: Topical calcineurin inhibitors are used as the second-line drugs for the treatment of vitiligo. However, no summarization of all effectiveness has been evaluated. Researchers are interested in the subject.Objective: This study aimed to review literature systematically on the effectiveness of topical calcineurin inhibitors in vitiligo.Method: A systematic review search of databases that met the inclusion and exclusion criteria. Relevant data were obtained from PubMed. A systematic search of databases resulted in keywords such as topical calcineurin inhibitors and vitiligo. Comparative randomized controlled trials investigating topical calcineurin inhibitors in vitiligo were searched, written in English. Two independent authors evaluated the title, abstract, quality of studies, and extract data.Result: A systematic search of databases revealed that 4 articles met the inclusion and exclusion criteria from 33 articles. The result showed that topical calcineurin inhibitors be effective for the treatment of vitiligo.Conclusion: Topical calcineurin inhibitors can be used as an alternative for the treatment of vitiligo. However, randomized controlled trials are still needed in order to can be synthesized and analyzed for meta-analysis and confirm the effectiveness of topical calcineurin inhibitors.


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How to Cite

Samtip P, Sriphet B, Khaonim K. A Systematic Review on the Effectiveness of Topical Calcineurin Inhibitors in Vitiligo. j dept med ser [Internet]. 2021 Sep. 3 [cited 2022 Oct. 1];46(2):30-8. Available from: https://he02.tci-thaijo.org/index.php/JDMS/article/view/253526



Original Article