Factors Associated with Extended Duration of Treatment in New Smear Positive Pulmonary Tuberculosis Patients in Bandung Crown Prince Hospital, Udonthani Province

Abstract

Background: Tuberculosis (TB) was a global public health emergency and required multiple drugs treatment for many months.Objective: The study determined factors associated with extended duration of treatment in new smear positive pulmonary tuberculosis patients.Methods: A retrospective cohort study was conducted in Bandung Crown Prince Hospital, Udonthani Province. Medical records of new TB patients with smear positive from 1st October 2016 – 30th September 2019 had been reviewed from the date of diagnosis and during treatment until patients cured or completed. Patient characteristics, co-disease, adherence and adverse drug reactions were analyzed for frequency, percentage, and standard deviation. Chi-square and Binary logistic regression analyzed factors affecting duration of treatment.Results: This study included 243 tuberculosis patients. Patients with extended treatment duration were 37.45%, the average duration of treatment was 7.23 ±1.93 months. Individual factors found to have influence duration of treatment were body weight, sputum smear, patient types and adverse drug reaction reports in statistically significant manner (p<0.05). Factors affecting duration of treatment were adverse drug reactions (adjusted OR 2.5, 95% CI = 1.41, 8.65; p-value <0.001).Conclusion: Adverse drug reaction is significantly associated with the duration of treatment. Healthcare facilities should have close monitoring to reduce the rate of extension of the treatment period.