Effects and Safety of Cannabis Sublingual Oil THC 1.7% w/v Formula in Patients with End Stage Cancers in Medical Cannabis Clinic, Chao Phya Abhiabhubejhr Hospital


  • Waleerat Kraikosol, M.D. Chao Phya Abhaibhubejhr Hospital
  • Arsala Chaocharoen, Pharm.D. Chao Phya Abhaibhubejhr Hospital
  • Paloch Laemluang, Pharmacy student Faculty of Pharmaceutical Sciences, Chulalongkorn University
  • Natdanai Musigawong, B.Pharm Chao Phya Abhaibhubejhr Hospital
  • Pakakrong Kwankhao, Ph.D. Chao Phya Abhaibhubejhr Hospital


Cannabis sublingual oil, End stage cancers, Palliative care


Background: There is insufficient evidence for medical cannabis to support appropriate use in health system.Objectives: This study evaluated the effects and safety of cannabis sublingual oil THC 1.7% w/v formula in patients with end stage cancers.Method: Retrospective study from medical records of 103 patients who attended medical cannabis clinic and had at least one time of follow up.Results: According to 6 times monthly check-ups, the results showed that cannabis sublingual oil THC 1.7% w/v formula could help relieving pain, anorexia, insomnia, and anxiety significantly. Quality of life of these patients tended to increase especially last three months. The median of utility score of the EQ-5D-5L questionnaire before start cannabis sublingual oil THC 1.7% w/v was 0.767 and increased to 0.928 on the sixth month after. The incidence of adverse events was 30.10% which majority of events were manageable. However, only 11 patients had completed the 6-month follow-up, accounting for 77.3% dropout rate.Conclusions: Cannabis sublingual oil THC 1.7% w/v formula could improve quality of life and be well tolerated in patients with end stage cancers. However, it needs further studies in the large sample.


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How to Cite

Kraikosol W, Chaocharoen A, Laemluang P, Musigawong N, Kwankhao P. Effects and Safety of Cannabis Sublingual Oil THC 1.7% w/v Formula in Patients with End Stage Cancers in Medical Cannabis Clinic, Chao Phya Abhiabhubejhr Hospital. j dept med ser [Internet]. 2021 Nov. 30 [cited 2023 Feb. 2];46(3):50-9. Available from: https://he02.tci-thaijo.org/index.php/JDMS/article/view/255040



Original Article