Identification Rate of Sentinel Lymph Node Biopsy using Single Technique (Isosulfan Blue Dye) in Early Breast Cancer in Lopburi Cancer Hospital


  • Kanchana Areerattanavet, M.D. Lopburi Cancer Hospital


Lymphatic mapping, Sentinel lymph node, Breast cancer, Lopburi Cancer Hospital


Background: Breast cancer is currently the most common cancer of woman in worldwide and also in Thailand. In the past, radical axillary surgery had been an integral part of breast cancer treatment to staging and provided locoregional control. During the past decade, surgical paradigm changed from standard axillary lymph node dissection for early breast cancer patients to sentinel lymph node biopsy (SLNB) due to increasing evidence indicated that was safe and acceptably accurate method for determining axillary node staging in early-stage breast cancer patients without clinically axilla lymph node involvement. Sentinel lymph node was identified by lymphatic mapping. There were 3 techniques of lymphatic mapping; blue dye alone, radioisotope alone, or a combination of blue dye and radioisotope. In this study, we used blue dye alone for lymphatic mapping due to simplicity and low cost.Objective: The purpose of this study to report an identification rate of sentinel lymph node using isosulfan blue dye alone in breast cancer patients at Lopburi Cancer Hospital and to find out factors that might affect the rate of sentinel lymph node identification.Methods: This study was retrospective observational study. Patients were enrolled between 1st August 2017 and 30th April 2020. Eligible criteria included T1 or T2 invasive breast cancer and all T size of ductal carcinoma in situ who underwent mastectomy, with all clinically negative axillary lymph nodes. All patients performed sentinel lymph node biopsy by using 1% isosulfan blue dye alone for lymphatic mapping at Lopburi Cancer Hospital.Results: A total of 74 female breast cancer patients representing 75 cases (1 bilateral breast cancer case) underwent SLNB using isosulfan blue dye alone. A sentinel node was identified in 71 of 75 cases (94.67%).Conclusion: The identification rate of sentinel lymph node biopsy using isosulfan blue dye alone in early breast cancer at Lopburi Cancer Hospital are acceptable and feasible.


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How to Cite

Areerattanavet K. Identification Rate of Sentinel Lymph Node Biopsy using Single Technique (Isosulfan Blue Dye) in Early Breast Cancer in Lopburi Cancer Hospital. j dept med ser [Internet]. 2021 Nov. 30 [cited 2023 Jan. 31];46(3):73-80. Available from:



Original Article