Risk Factors of Low Neutrophils in Cancer Patients at Lop Buri Cancer Hospital

Abstract

Background: Neutropenia is common after receiving chemotherapy and increases your risk for infections.Fever during neutropenia could be a very serious consequence. Objective: To study the risk factors of neutropeniaand to determine the incidence of febrile neutropenia in cancer patients at Lop Buri Cancer Hospital. Method: Thiswas a cross-sectional study reviewing the medical records of 307 people diagnosed with cancer and their identifiedstage. Data were collected from October 1, 2019, to September 30, 2020, using the data collection on the incidenceof neutrophil neutropenia in cancer patients. The relationship between factors was analyzed using the chi-squaretest and binary logistic regression analysis. Results: From the sample of 307 patients, it was found that the riskfactors associated with neutrophil neutropenia were statistically significant at the 0.05 significance level, which wasstage 2 disease (OR 0.18, p-value = 0.001), number of chemotherapy doses 2-6 (OR 2.51, p-value = 0.006), and initialneutrophil leukocyte levels that were lower than normal (OR 4.67, p-value < 0.001). Initial neutrophil leukocytelevels grade 1 (OR 3.41, p-value = 0.005) and grade 2 (OR 8.95, p-value = 0.001) were not significantly correlated.The following complications were fever (OR 5.33, p-value = 0.031). fatigue (OR 4.92, p-value = 0.011) and burning/urinating. Sparse (OR 16.13, p-value = 0.014) compared with those with normal neutrophil leukemia. Statisticallysignificant (p-value <0.001). Conclusions: Both patients with normal baseline neutrophil leukocyte levels and lowinitial neutrophil leukocyte levels could have a lower neutrophil level as well as low neutrophil leukocytosis afterundergoing treatment. Therefore, there should be treatment guidelines for every patient in order to prevent thedevelopment of low neutrophils or their recurrence, along with complications from neutropenia.