The Study of Adverse Reactions of Fundus Fluorescein Angiography and Indocyanine Green Angiography

Abstract

Background: Fundus fluorescein angiography (FFA) and/or indocyanine green (ICG) play significant rolesnot only in abnormal investigation but also in the diagnosis and follow-up treatment of retina and choroid. Theinformation from a study of adverse reactions of FFA and/ or ICG will be useful for guideline development. It mayreduce the severity level of FFA and/or ICG adverse reactions. Objective: To determine the severity level andfactors related to the occurrence of adverse reactions. Method: Data were collected from 2,936 medical recordsat Mettapracharak (Watraikhing) Hospital from January 2561 to December 2563, but the present analysis was basedon 2,682 fundus fluorescein angiography patients, who were followed by inclusion criteria. Statistics for analysiswere inferential statistics, chi-square, and odds ratio. Result: The reactions were mild (1.9%) or moderate (1.8%).98 patients (3.7%) who had adverse reactions were male (68.4%), with an average age of 48 years old (SD = 16.05),and without underlying disease (57.1%). Male patients had 1.5 times more adverse reactions than females (OR 1.5,95%CI: 1.005, 2.389, p = .05). Patients with underlying diseases had a lower ratio of adverse reactions than patientsthat did not have underlying diseases (42 VS 56, OR 0.56, 95%CI: 0.370, 0.837, p = .01). The other factors haveshown that there was no significant number of patients with adverse reactions. Conclusion: Male patients had moreadverse reactions than females. Patients with underlying diseases had a lower ratio of adverse reactions than thosewithout underlying disease.