Incidence and Factors Associated with Hyperparathyroidism Following Kidney Transplantation
Keywords:
Kidney transplantation (KT), Hyperparathyroidism (HPT), Hyperparathyroidism following kidney transplantationAbstract
Background: Kidney transplantation (KT) can reverse renal function and improve patient survival while the intact parathyroid hormone (iPTH) level persists high in some kidney transplant recipients (KTRs). Thus, we examined the incidence and factors associated with post-KT hyperparathyroidism. Objectives: We aimed to examine the incidence and factors associated with post-KT hyperparathyroidism. Methods: A single center, retrospective study of 312 KTRs between January 1997 and December 2020 was investigated. We included KTRs having serum iPTH level after 6 months post-KT with stable renal function. KTRs without post-KT iPTH level were excluded. We defined hyperparathyroidism (HPT) according to estimated glomerular filtration rate (eGFR); iPTH >65 and >130 pg/mL for eGFR ≥60 and <60 mL/min/1.73 m2, respectively. We divided patients into groups of post-KT HPT and those without HPT. We analyzed the incidence, associated factors and compared between groups. STATA version 15.1 was used for statistic analyses. Results: The data revealed 144 KTRs, we found that incidence of post-KT HPT was 85 (59.0%). Among these, there were 67 patients having pre-transplant iPTH level and 33 (49.3%) were defined as persistent HPT. Factors associated with post-KT HPT were female and high pre-transplant iPTH level. We found one case of biopsy-proven nephrocalcinosis, might be the sequelae of post-KT HPT. Neither report of death nor cardiovascular events relating to post-KT HPT. Conclusion: Our study showed that the incidence of hyperparathyroidism following kidney transplantation accounted for 59.0% despite the recovery of renal function. Female and high pre-transplant iPTH level were its associated factors.
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