Effectiveness of Hyperthermia Combined with Radiation Therapy for Non-small Cell Lung Cancer: A Systematic Review
Keywords:
Hyperthermia, Radiation Therapy, Non - Small Cell Lung CancerAbstract
Background: Hyperthermia is a therapeutic technique that involves increasing the temperature of a tumor to help destroy and kill cancer cells without harming normal tissue. It is commonly used alongside other cancer treatments, such as radiotherapy or chemotherapy. However, its effectiveness depends on many factors, and the right method must be used to achieve efficiency. Objective: Our systematic review and meta-analysis aimed to compare the effectiveness of hyperthermia combined with radiation therapy versus radiation therapy alone in treating non-small cell lung cancer. Method: We used search methods to identify relevant studies in electronic databases, including the Cochrane Central Register of Controlled Trials (CENTRAL) and MEDLINE database via PubMed. Analyses were performed using the Reference Manager (RevMan). Result: Three studies with 155 patients were enrolled, including 72 patients in the hyperthermia combined with radiotherapy (RT+HT) group and 83 patients in the Radiation alone (RT) group. Treatment with hyperthermia combined with radiotherapy resulted in a large increase in 1 - year progression-free survival (1 - y PFS) compared to radiation alone hazard ratio (HR) 0.53, 95% confidence interval (CI) 0.35, 0.81, p = .003). including increasing complete response (risk ratio (RR) 4.43, 95% CI 1.13, 16.74; p = .03). However, 1 - year overall survival between hyperthermia combined with radiotherapy and radiation alone groups showed little or no difference in risk of mortality and partial response (HR 0.71, 95% CI 0.44, 1.16, p = .18) and (RR 1.01, 95% CI 0.54, 1.35; p = .94). Conclusion: Due to the limited resources for analysis, our study suggests that hyperthermia combined with radiation therapy affects 1 - year progression - free survival and complete response in patients with advanced non-small cell lung cancer.
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