Using of Platelet - rich Fibrin for the Treatment of Intrabony Defects: A Systematic Review and Meta – analysis
Keywords:
Periodontal disease treatment, Platelet rich fibrin, Intrabony defects, Meta-analysisAbstract
Background: Platelet rich fibrin (PRF), the second generation of platelet rich plasma (PRP) has been used for intrabony defect treatment. According to the fibrin matrix properties, PRF could release growth factor slowly and promote the healing of periodontal surgery both in soft and hard tissue. Moreover, it is useful for periodontal regeneration. Objective: To quantitatively find out how platelet rich fibrin could be used in the treatment of intrabony defects in combination with periodontal surgery, and platelet rich fbrin preparation affect the treatment of intrabony defects. Method: Systematically retrieved data from PubMed database and Google Scholar by selecting only English or Thai articles from 2010 to 2022. All 27 accepted articles were meta - analyzed by collecting the results of the clinical measurement which were the change of periodontal pocket depth and the clinical attachment level including the results of radiographic measurement. Results: The evidences suggested that the platelet rich fibrin with periodontal surgery group which was able to reduce periodontal pocket depth greater than in the control group (SMD = 1.793; 95% CI 1.347, 2.238, p < .001), and was increase the clinical attachment level greater than in the control group (SMD = 1.798; 95% CI 1.349, 2.248, p < .001). In addition, it was also able to increase the length of bone in the intrabony defects (SMD = 3.404; 95% CI 2.636, 4.171, p < .001), but disable to concluded because the data were heterogeneity (I2 = 92.0%, I2 = 92.3%, I2 = 94.9%) which may not cause from only preparing PRF but also from other factors. Conclusion: Platelet - rich fibrin can be used with open flap debridement as resulted in reduction of the periodontal pocket depth and increase the clinical attachment level and bone in the intrabony defects greater than the treatment with open flap debridement alone but cannot conclude because of the heterogeneity of data.
References
Patel GK, Gaekwad SS, Gujjari SK, S C VK. Platelet - rich fbrin in regeneration of intrabony defects: a randomized controlled trial. J Periodontol 2017;88(11):1192-9.
Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classifcation of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fbrin (L-PRF). Trends Biotechnol 2009;27(3):158-67.
He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet - rich fbrin (PRF) and platelet - rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108(5):707-13.
Ajwani H, Shetty S, Gopalakrishnan D, Kathariya R, Kulloli A, Dolas RS, et al. Comparative evaluation of platelet - rich fbrin biomaterial and open flap debridement in the treatment of two and three wall intrabony defects. J Int Oral Health 2015;7(4):32-7.
Brown LF, Lanir N, McDonagh J, Tognazzi K, Dvorak AM, Dvorak HF. Fibroblast migration in fbrin gel matrices. Am J Pathol 1993;142(1):273-83.
Strauss FJ, Stähli A, Gruber R. The use of platelet - rich fbrin to enhance the outcomes of implant therapy: A systematic review. Clin Oral Implants Res 2018;29(Suppl 18):6-19.
He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet - rich fbrin (PRF) and platelet - rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;108(5):707-13.
Ajwani H, Shetty S, Gopalakrishnan D, Kathariya R, Kulloli A, Dolas RS, et al. Comparative evaluation of platelet - rich fbrin biomaterial and open flap debridement in the treatment of two and three wall intrabony defects. J Int Oral Health 2015;7(4):32-7.
Panda S, Doraiswamy J, Malaiappan S, Varghese SS, Del Fabbro M. Additive effect of autologous platelet concentrates in treatment of intrabony defects: a systematic review and meta - analysis. J Investig Clin Dent 2016;7(1):13-26.
Chen L, Ding Y, Cheng G, Meng S. Use of Platelet - Rich Fibrin in the treatment of periodontal intrabony defects: a systematic review and meta - analysis. Biomed Res Int 2021;2021:6669168.
Castro AB, Meschi N, Temmerman A, Pinto N, Lambrechts P, Teughels W, et al. Regenerative potential of leucocyte - and platelet - rich fbrin. Part A: intra - bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta - analysis. J Clin Periodontol 2017;44(1):67-82.
Tarallo F, Mancini L, Pitzurra L, Bizzarro S, Tepedino M, Marchetti E. Use of platelet - rich fbrin in the treatment of grade 2 furcation defects: systematic review and meta - analysis. J Clin Med 2020;9(7):2104.
Panda S, Satpathy A, Chandra Das A, Kumar M, Mishra L, Gupta S, et al. Additive effect of platelet rich fbrin with coronally advanced flap procedure in root coverage of Miller’s class I and II recession defects - a PRISMA compliant systematic review and meta - analysis. Materials (Basel) 2020;13(19):4314.
Li F, Jiang P, Pan J, Liu C, Zheng L. Synergistic application of platelet - rich fibrin and 1% alendronate in periodontal bone regeneration: a meta - analysis. Biomed Res Int 2019;2019:9148183.
Li R, Liu Y, Xu T, Zhao H, Hou J, Wu Y, et al. The additional effect of autologous platelet concentrates to coronally advanced flap in the treatment of gingival recessions: a systematic review and meta - analysis. Biomed Res Int 2019;2019:2587245.
Panda S, Sankari M, Satpathy A, Jayakumar D, Mozzati M, Mortellaro C, et al. Adjunctive effect of autologus platelet - rich fbrin to barrier membrane in the treatment of periodontal intrabony defects. J Craniofac Surg 2016;27(3):691-6.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Department of Medical Services, Ministry of Public Health
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของกรมการแพทย์ กระทรวงสาธารณสุข
ข้อความและข้อคิดเห็นต่างๆ เป็นของผู้เขียนบทความ ไม่ใช่ความเห็นของกองบรรณาธิการหรือของวารสารกรมการแพทย์
