Factors Related to Survival Rate in Breast Cancer Patients Undergoing Treatments at Lampang Cancer Hospital

Abstract

Background: Breast cancer is the most common cancer among Thai women and worldwide, as well as the main treatment options for breast cancer, rapidly and accuracy diagnosis to improving survival rates for breast cancer patients. Objective: This study aimed to evaluate overall survival (OS) of breast cancer and to determine prognostic factors of survival in breast cancer patients undergoing treatments at the Lampang Cancer Hospital. Method: This study was a retrospective cohort study. The data of patients diagnosed with breast cancer from 2010 to 2015 were derived from breast cancer databased of Lampang Cancer Hospital. The vital status of patients was followed-up until 31^st December 2021. Kaplan Meier method was used to estimate the 5-year and 10-year survival. Cox proportional hazard regression model was to determine the prognostic factors affecting survival for univariate and multivariate analyses (at a significance level of .05) using R program. Results: Among 1,841 patients, 1,397 was included in survival analysis. The 5-year and 10-year overall survival in breast cancer patients were 75.4% and 63.8%, respectively. The 5-year survival by stages I, II, III, and IV were 93.4%, 83.7%, 64.1%, and 25.6% respectively, and the 10-year survival were 85.3%, 76.4%, 47.6%, and 8.7% respectively. The results from multivariate analysis found that increasing of stage, tumor size, and occupation had significantly increased risk of breast cancer death (p-value < .001). While the positive ER receptors, surgery type (wide excision), and complete treatment factor had significantly decreased risk rate of breast cancer death (p-value < .001). Conclusion: Breast cancer treatment plans that consider both clinical and patient factors are essential for improving survival outcomes for patients.