SMARCA4-deficient Sinonasal Carcinoma: A Case Report and Literature Review
Keywords:
SMARCA4, BRG1, SWI/SNF complex-deficient sinonasal carcinomaAbstract
SMARCA4-deficient sinonasal carcinoma a subtype of SWI/SNF complex-deficient sinonasal carcinomas is a rare, highly aggressive sinonasal malignancy with only 23 cases reported in the literature to date. We present a case of a 70-year-old woman referred to our institution with a preliminary diagnosis of small cell neuroendocrine carcinoma. A computed tomography revealed a nasal cavity mass extending into the sphenoid sinus and nasopharynx, without involvement of the skull base, pterygoid, or orbit. Histologic examination revealed monomorphic, large, undifferentiated neoplastic cells that showed loss of SMARCA4 expression. SMARCA4-deficient sinonasal carcinoma is a rare malignant neoplasm with an aggressive clinical course and poor prognosis. Diagnosis typically relies on a combination of histologic findings and immunohistochemical staining to identify this high-grade malignancy.
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