Effect of Silver Diamine Fluoride as Cariostatic Agent in Irradiated Permanent Teeth

Authors

  • Niracha Charoenkitjatorn Institute of Dentistry
  • On-ong Mungkung Institute of Dentistry
  • Esthera Prateeptongkum Institute of Dentistry

Keywords:

Silver diamine fluoride, Permanent tooth, Irradiation, Remineralization

Abstract

Background: Oral and pharyngeal cancers have a high incidence among the elderly population. Most patients receive radiotherapy as a treatment. Radiation-induced dental caries is a common long-term complication that may lead to infection of jawbone and result in risk of osteoradionecrosis. Silver diamine fluoride (SDF) at 38% concentration is effective in inhibiting formation of new caries and arrested root caries in older adults. However, there is a lack of studies examining the effects of SDF on remineralization in permanent teeth that have undergone radiotherapy and developed caries. Objective: This study aims to investigate the effects of SDF on promoting remineralization in irradiated teeth with artificial caries lesions. Method: A total of forty permanent tooth specimens were prepared. All specimens were irradiated by fractional radiation to achieve a total dose of 70 Gy and created artificial caries lesions. 20 samples in each study group were applied with silver diamine fluoride (SDF) and 1,500 ppm fluoride toothpaste. Hydroxyapatite density was quantified by X-ray microcomputed tomography (µCT35) before and after application. Mean hydroxyapatite density and the percentage of remineralization in enamel and dentin were calculated and statistically analyzed by paired t test and unpaired t test. Result: The results demonstrate that SDF and fluoride toothpaste increased mineral density in enamel and dentin after application in all experimental groups. The mineral recovery percentage in enamel was statistically different between SDF and fluoride toothpaste applications. Furthermore, the percentage of mineral recovery in dentin after SDF application was higher than that of fluoride toothpaste. Conclusion: Treatment with SDF can increase mineral density in carious lesions and promote remineralization in irradiated teeth.

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Published

17-03-2025

How to Cite

1.
Charoenkitjatorn N, Mungkung O- ong, Prateeptongkum E. Effect of Silver Diamine Fluoride as Cariostatic Agent in Irradiated Permanent Teeth. J DMS [internet]. 2025 Mar. 17 [cited 2025 Mar. 20];50(1):131-8. available from: https://he02.tci-thaijo.org/index.php/JDMS/article/view/270784

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Original Article