The effectiveness of extemporaneous preparations of folic acid of Sisaket hospital

Abstract

This study aimed to evaluate the effectiveness of extemporaneous preparations of folic acid. This study employed research and development, quasi experimental, and observational research methods and was divided into two phases. Phase 1, formulation development the extemporaneous preparations by crushing 12 tablets of folic acid 5 mg into powder and diluted with syrup USP to a final volume of 60 ml and store at refrigerated temperature. The preparation had a yellow color, sweet taste, and slightly viscous. The physical, chemical, and microbiological stability was examined at days 0, 29, and 59. Results showed no physical changes, pH values of 6.08, 5.92, and 5.61, respectively. The folic acid content was 95.69 %LA, 98.25 %LA, and 92.85 %LA, respectively, no microbial contamination detected. Phase 2, the effectiveness of the preparation was evaluated by comparing hemoglobin and hematocrit levels of 19 patients with homozygous hemoglobin E before and after receiving the preparation. Adverse events and caregiver satisfaction were assessed by interviews with 42 caregivers. Data were analyzed using frequency, percentage, mean, and paired t-test statistics.

The results showed, hemoglobin and hematocrit levels increased statistically after receiving the preparation (9.72 ± 1.20 g/dl vs 10.29 ± 0.83 g/dl and 29.36 ± 3.24% vs 30.78 ± 1.84%, p < 0.05). The adverse event reported was dental caries. Caregivers was satisfaction with the preparation. In conclusion, the extemporaneous preparations of folic acid of Sisaket hospital is stable, effective, safe, and caregivers are satisfied.