Artesunate and Cancer Treatment: A Systematic Review
Keywords:
artesunate, cancer, systematic reviewAbstract
This systematic review aimed to study the effectiveness of Artesunate toward cancer treatment. The results of literature search strategy from 9 databases, between 2008 and 2017, using keywords showed that there were 123 studies related to Artesunate and cancer. All of which were screened and considered inclusion and exclusion criteria. Finally, there were 8 eligible studies in total. It comprised of 7 studies from PubMed and 1 study from Science Direct. The findings revealed that Artesunate suppresses tumor growth and induces apoptosis, non-apoptotic cell death, and Necrosis. Artesunate combined with chemotherapy using Cisplatin and Vinorelbine can elevate the short-term survival rate and prolong time to progression of the patients with cancer very less extra side effects.
References
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2. Virani S, Bilheem S, Chansaard W, Chitapanarux I, Daoprasert K, Khuanchana S, et al. National and Subnational Population-Based Incidence of Cancer in Thailand: Assessing Cancers with the Highest Burdens. Cancers (Basel). 2017;9(8).
3. Bayat Mokhtari R, Homayouni TS, Baluch N, Morgatskaya E, Kumar S, Das B, et al. Combination therapy in combating cancer. Oncotarget. 2017;8(23):38022-43.
4. Sliwkowski MX, Mellman I. Antibody therapeutics in cancer. Science. 2013;341(6151):1192-8.
5. Tu Y. The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nat Med. 2011;17(10):1217-20.
6. Chen C, Zheng X. Development of the new antimalarial drug pyronaridine: a review. Biomed Environ Sci. 1992;5(2):149-60.
7. Crespo-Ortiz MP, Wei MQ. Antitumor activity of artemisinin and its derivatives: from a well-known antimalarial agent to a potential anticancer drug. J Biomed Biotechnol. 2012;2012:247597.
8. Wang Q, Wu LM, Li AY, Zhao Y, Wang NP. [Experimental studies of antitumor effect of artesunate on liver cancer]. Zhongguo Zhong Yao Za Zhi. 2001;26(10):707-8, 20.
9. Efferth T, Dunstan H, Sauerbrey A, Miyachi H, Chitambar CR. The anti-malarial artesunate is also active against cancer. Int J Oncol. 2001;18(4):767-73.
10. Wang Q, Wu LM, Zhao Y, Zhang XL, Wang NP. [The anticancer effect of artesunate and its mechanism]. Yao Xue Xue Bao. 2002;37(6):477-8.
11. Cheng C, Ho WE, Goh FY, Guan SP, Kong LR, Lai WQ, et al. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One. 2011;6(6):e20932.
12. Cheng C, Ng DS, Chan TK, Guan SP, Ho WE, Koh AH, et al. Anti-allergic action of anti-malarial drug artesunate in experimental mast cell-mediated anaphylactic models. Allergy. 2013;68(2):195-203.
13. Ho WE, Cheng C, Peh HY, Xu F, Tannenbaum SR, Ong CN, et al. Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma. Free radical biology & medicine. 2012;53(3):498-507.
14. Tan SS, Ong B, Cheng C, Ho WE, Tam JK, Stewart AG, et al. The antimalarial drug artesunate inhibits primary human cultured airway smooth muscle cell proliferation. American journal of respiratory cell and molecular biology. 2014;50(2):451-8.
15. Efferth T, Romero MR, Wolf DG, Stamminger T, Marin JJ, Marschall M. The antiviral activities of artemisinin and artesunate. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2008;47(6):804-11.
16. Schnepf N, Corvo J, Pors MJ, Mazeron MC. Antiviral activity of ganciclovir and artesunate towards human cytomegalovirus in astrocytoma cells. Antiviral research. 2011;89(2):186-8.
17. Li, S. G., Chen, H. Y., Ou-Yang, C. S., Wang, X. X., Yang, Z. J., Tong, Y., & Cho, W. C. (2013). The efficacy of Chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: a systematic review and meta-analysis. PloS one, 8(2), e57604.
18. Randolph, J. J. (2009). A guide to writing the dissertation literature review. Practical assessment, research & evaluation, 14(13), 1-13.
19. Keele, S. (2007). Guidelines for performing systematic literature reviews in software engineering (Vol. 5). Technical report, Ver. 2.3 EBSE Technical Report. EBSE.
20. Joanna Briggs Institute. (2014). Joanna Briggs Institute reviewers’ manual: 2014 edition. Australia: The Joanna Briggs Institute.
21. Krishna, S., Ganapathi, S., Ster, I. C., Saeed, M. E., Cowan, M., Finlayson, C., ... & Kumar, D. (2015). A randomised, double blind, placebo-controlled pilot study of oral artesunate therapy for colorectal cancer. EBioMedicine, 2(1), 82-90.
22. Zhang, Z. Y., Yu, S. Q., Miao, L. Y., Huang, X. Y., Zhang, X. P., Zhu, Y. P., ... & Li, D. Q. (2008). Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: a randomized controlled trial. Zhong xi yi jie he xue bao= Journal of Chinese integrative medicine, 6(2), 134-138.
23. Zhang, P., Luo, H. S., Li, M., & Tan, S. Y. (2015). Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2. OncoTargets and therapy, 8, 845.
24. Hamacher-Brady, A., Stein, H. A., Turschner, S., Toegel, I., Mora, R., Jennewein, N., ... & Brady, N. R. (2011). Artesunate activates mitochondrial apoptosis in breast cancer cells via iron-catalyzed lysosomal reactive oxygen species production. Journal of Biological Chemistry, 286(8), 6587-6601.
25. Du, J. H., Zhang, H. D., Ma, Z. J., & Ji, K. M. (2010). Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo. Cancer chemotherapy and pharmacology, 65(5), 895-902.
26. Berdelle, N., Nikolova, T., Quiros, S., Efferth, T., & Kaina, B. (2011). Artesunate induces oxidative DNA damage, sustained DNA double-strand breaks, and the ATM/ATR damage response in cancer cells. Molecular cancer therapeutics, 10(12), 2224-2233.
27. Michaelsen, F. W., Saeed, M. E., Schwarzkopf, J., & Efferth, T. (2015). Activity of Artemisia annua and artemisinin derivatives, in prostate carcinoma. Phytomedicine, 22(14), 1223-1231.
28. Rasheed, S. A. K., Efferth, T., Asangani, I. A., & Allgayer, H. (2010). First evidence that the antimalarial drug artesunate inhibits invasion and in vivo metastasis in lung cancer by targeting essential extracellular proteases. International journal of cancer, 127(6), 1475-1485.
29. Efferth, T., Giaisi, M., Merling, A., Krammer, P. H., & Li-Weber, M. (2007). Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells. PloS one, 2(8), e693.
30. Efferth, T., Dunstan, H., Sauerbrey, A., Miyachi, H., & Chitambar, C. R. (2001). The anti-malarial artesunate is also active against cancer. International journal of oncology, 18(4), 767-773.
31. Bachmeier, B., Fichtner, I., Killian, P. H., Kronski, E., Pfeffer, U., & Efferth, T. (2011). Development of resistance towards artesunate in MDA-MB-231 human breast cancer cells. PLoS One, 6(5), e20550.
