Trends in drug resistance incidence of Pediatric patients Sichon Hospital, Nakhon Sri Thammarat Province

Abstract

Introduction: Antibiotic resistance is a significant problem of health care system. The overuse and misuse of antibiotics are key factors contributing to antibiotic resistance. The improper use of antibiotics lead to a rapidly growing of antibiotic resistant infection. Therefore, it may become a cause of severe symptoms which extent patient’s length of stay in the hospital and high cost of treatment. Furthermore, the worst situation can increase the high chance of death for infected patients.
Objectives: The retrospective study was aimed to study the situation of infection in Pediatric patients and to study the trends of those incidences resulting in antibiotic-resistance in Sichon hospital Nakhon Sri Thammarat province.
Methods: Data were collected from document reviewing of 449 patient’s documents that appeared a positive culture laboratory results from 1 January 2014 to 31 December 2016. Data were using frequency and percentage statistics.
Results: The study results revealed that There were 14 infection types that spread to pediatric patients in Sichon hospital,
Nakhon Sri Thammarat. Trends in drug resistance incidence of Pediatric patients can be summarized that K. pneumoniae producing ESBL and E. coli producing were decreased incidence rate compared to the previous study which had undertaken in the tertiary hospital. In addition, the study found that Pseudomonas aeruginosa had been well sensitively response to some specific antibiotics; Gentamicin, Ciprofloxacin, Imipenem, Ceftazidime, Amikacin and Cefoperazone/Sulbactam. Morever, Acinetobactor baumannii that normally has high level of resistance rate and high prevalence of infection especially in the tertiary hospital had been well sensitively response to some specific antibiotics; Gentamicin Ciprofloxacin, Ceftazidime, Amikacin, Imipenem and Cefoperazone/Sulbactam. However, during the period of data collection, no incident rate of MRSA had been reported.
Conclusions: Most of pediatric patients who were receiving treatment at Sichon hospital were not under critical stage and having any illness that affected to immunological system which can develop any kind of disease. Therefore, the incidence of antimicrobialresistance is still lower rate comparing with the other regional hospital. As a result from the study, it can be beneficial for healthcare professional to select a best antibiotic giving treatment for pediatric patients. Consequently, it will be reduce patients cost of treatment, length of stay, any complications regarding infection and finally can be decreased the pediatric patient mortality rate in the future.