Clinical syndrome and pathological diagnosis of Glomerular Diseases in Vachira phuket Hospital
Keywords:
Glomerular diseases, Clinical syndrome, renal pathologyAbstract
Background: Glomerular disease is a common disease in clinical practice and the leading cause of the end stage renal disease. Most of the patients presented with multiple clinical syndromes which depended on the renal pathology without any epidemiological studies were available in Vachira Phuket hospital and this area. Clinical characteristics and kidney biopsy were important roles for diagnosis and developing appropriate treatment regimens.
Objective: To study the Correlation between clinical syndrome and the pathologic results of kidney biopsy of the patients with Glomerular disease at the nephro clinic, Vachira Phuket hospital.
Method: This study was a descriptive retrospective study medical records of patients who were diagnosed with Glomerular disease at nephro clinic, Vachira Phuket hospital between January 2013 and December 2015, were reviewed. Patient’s demographic data, clinical characteristics, details of laboratory tests, renal pathology, 6 months follow up and treatment outcomes were recorded.
Results: A Total of 65 patients kidney biopsy data were collected during this period. The ratio of female to male was 1.7:1, average age was 41.52 years (SD = 14.36). The patients were primary glomerular disease 52.3% and secondary glomerular disease 47.7%. The most common renal pathological findings were Lupus nephritis (LN), IgA nephropathy (IgAN) and Minimal Change Disease (MCD) accounting for 24.6%, 20% and 13.9%, respectively. The most common clinical syndrome were Nephrotic nephritis syndrome, Nephrotic syndrome and Asymptomatic urinary abnormalities 36.9%, 32.3% and 15.4%, respectively. The most of treatment response show clinical syndrome and renal pathology were Nephrotic nephritis syndrome and Lupus nephritis (LN).The patients whom were poor response to treatment presented with Nephrotic syndrome, IgA nephropathy and diabetic nephropathy.
Conclusion: The study of clinical characteristics, results of kidney biopsy pathology of Glomerular disease patients in Vachira Phuket Hospital, this study will be apply to the patients’ treatment plan effectively in the area. The follow up and data analyzed should be done to improve and enhance clinical outcomes within this group.
References
care centre. Int J Res Med Sci 2015; 3:2004-13.
Daneshpajouhnejad P, Behzadi E, Amoushahi S, Aghabozorgi A, Farmani A, Hosseini S, et al. A Six-year Survey of the Spectrum of Renal Disorders on Native
Kidney Biopsy Results in Central Iran and a Review of Literature. Saudi J Kidney Dis Transpl; 2018; 29:658-70
Modugumudi ASN, Venkata PB, Bottla SKV, Kottu R, Nandyala R, Patnayak R,et al. A study of primary glomerular diseases in adults; clinical, histopathological
and immunofluorescence correlations. J Nephropharmacol; 2016; 5: 91–97.
Oliveira LB, Cobo EC, Machado J, Custodio FB, Silva MV, Oliveira FA, et al. Clinical and epidemiological prevalence of glomerulopathies elderly in the city of
Uberaba. J Bras Nefrol; 2015; 37:166-70.
Ayar Y, Ersoy A, Isiktas E, Ocakoglu G, Yildiz A, Oruc A, et al. The analysis of patients with primary and secondary glomerular diseases: A single-center
experience. HK J Nep; 2016;19: 28-35.
Valencia VC, CruZ CO, Fuentes JGB, Ramirez FF, Michel RP, Aragaki Y, et al. Epidemiology of glomerular disease in adults: A database review. Gac Med
Mex; 2014; 150: 403-8.
รัตนา ชวนะสุนทรพจน์และคณะ. การปรับปรุงผลทางคลินิกในการรักษาโรคไต ผ่านระบบทะเบียนโรคโกลเมอรูลัสในประเทศไทย.สถาบันวิจัยระบบสาธารณสุข [อินเทอร์เน็ต].
2560 [เข้าถึงเมื่อ 10 ตุลาคม 2561]:4-20. เข้าถึงได้จาก: http://kb.hsri.or.th/dspace/bitstream/handle/11228/4803/hs2374.pdf?sequence=3&isAllowed=y
บัญชา สถิระพจน์, ศรา อภัยจิตต์ ,อุปถัมภ์ ศุภสินธ์. ลักษณะอาการทางคลินิก และพยาธิวิทยาทางไตในผู้ป่วยโรคไตอักเสบในโรงพยาบาลพระมงกุฎเกล้า. เวชสารแพทย์ทหารบก 2553; 2: 53-64.
มนต์ชัย ศิริบำรุงวงศ์. โรคไตที่พบในการตรวจชิ้นเนื้อไตของผู้ป่วยโรงพยาบาลตราด.วารสารศูนย์การศึกษาแพทย์ศาสตร์คลินิกโรงพยาบาลพระปกเกล้า 2551; 4:339-47.
สมาคมโรคไตแห่งประเทศไทย. Thailand Renal Replacement Therapy Registry 2015 Report [อินเทอร์เน็ต]. กรุงเทพฯ; 2559 [เข้าถึงเมื่อ 9 กันยายน 2561]. เข้าถึง
ได้จาก : http://www.nephrothai.org/im-ages/Final_TRT_report_2015_.pdf
National Kidney Foundation. Glomerular disease: What you need to know [Internet].2014 [Cited 2018 June 15]. Available from:https://www.kidney.org/sites/
default/files/12-10-6139_glomerulard-isease.pdf
เกื้อเกียรติ ประดิษฐ์พรศิลป์. Glomerular disease.ใน: วิทยา ศรีดามา (บรรณาธิการ).ตำราอายุรศาสตร์ 2. พิมพ์ครั้งที่ 5.กรุงเทพมหานคร: โรงพิมพ์จุฬาลงกรณ์
มหาวิทยาลัย; 2550.179-214.
Chiu HF, Chen H, Lu KC, Shu KH. Distribution of glomerular diseases in Taiwan: preliminary report of National Renal Biopsy Registry–publication on behalf
of Taiwan Society of Nephrology. BMC Nephrology; 2018; 19:1-10.
Chang JH, Kim DK, Kim HW, Park SY, Yoo TH, Kim BS, et al. Changing prevalence of glomerular diseases in Korean adults: a review of 20 years of experience.
Nephrol Dial Transplant; 2009; 24:2406–10. 15. Riyami D, Shaaili K, Bulushi Y, Dhahli A, Date A. The Spectrum of Glomerular Diseases on Renal Biopsy: Data from
A Single Tertiary Center In Oman. Oman Med J; 2013; 3:213-15.
