The prevalence of extended spectrum Beta-lactamase producing in K.pneumoniae and E.coli at Phatthalung hospital

Abstract

              Drug resistance in Enterobacteriaceae is the most common mechanism resulted by producing Extended–Spectrum -lactamase (ESBLs) of bacteria, especially, K.pneumoniae and E.coli. This retrospective descriptive study aimed to explore the prevalence of K.pneumoniae and E.coli which producing ESBLs and their sensitivity to group ofcephalosporins. This study collected data from microbiology reports of all clinical specimens of the Laboratory Department at Phatthalung hospital from 1 January 2010 to 31 December 2014 and descriptive statistic was used to analyze these retrospective data. As a result, 9, 413 strains of K.pneumoniae and E.coli were found and 3,444 of them produced ESBLs (36.58%). While, 1,849 K.pneumoniae strains (38.66%) and 1,595 E.coli strains
(33.44%) producing ESBLs were identified. Regarding to host, 59.61% of ESBLs belonged to male and 24.24% of ESBLs occurred in adultsaged between 71 to 80 years old. Most K.pneumoniae and E.coli strains were reported occurring in Medicine wards, 55.54% and 54.80% respectively. Regarding to specimen types, K.pneumoniae producing ESBLs were mostly from sputum (65.22%), while E. coli producing ESBLs were mostly from urine (58.75%). For drug sensitivity, 99.87%, 99.75%, .99.66% and 94.19% of these K.pneumoniae strains presented good response to imipenem, meropenem, amikacin and gentamicin, respectively. While, 92.07%, 99.70%, and 91.62% of theseE. coli strains presented good response to gentamicin, amikacin and cefoperazole/sulbactam, respectively. Significantly, all of these E.coli strains had shown good response to imipenem and meropenem.