Relationship between HPV Typing Non 16/18 and the results of the Liquid Base Cytology test of Thai women undergoing cervical cancer screening

Abstract

Background: Infection with papillomavirus (HPV), encompassing types 16/18 as well as non 16/18 variants, presents a heightened susceptivity to the development of cervical cancer. It is imperative to underscore that the detection of non 16/18 HPV strains necessitates confirmation through Liquid Base Cytology screening methodology.

Objective: This retrospective study aimed to study the relationship between HPV Type Non 16/18 and the results of the Liquid Base Cytology test of Thai women undergoing cervical cancer screening.

Method: The purposive sampling technique was used for selecting a Thai woman undergoing cervical cancer screening at Sichon Hospital, Nakhon Si Thammarat Province, and has the HPV DNA Test results Typing Non 16/18 for the fiscal year 2022, numbering 144 cases. Data were analyzed using descriptive statistics, finding frequencies, and percentages, and finding relationships using chi-square statistics and Fisher extract tests.

Results: The results of the study found that Thai women who went for cervical cancer screening and had HPV DNA Test results as Type Non 16/18 with an average age of 46.11 ± 7.55 years, with an age range of 40-49 years (40.3%), HPV Multiple type 22 cases (15.3%), single type 122 cases (84.7%). The first 3 most common HPV types were 58 (23.6%), 52 (16%), and 51 (14.6%) with 31 (14.6%) having test results by the normal liquid base cytology method, including Negative for Intraepithelial Lesion or malignancy for 79 cases (54.9%) and positive test results for 65 cases, accounting for 45.1% of the number of positive test results. Abnormalities were found in 31 cases of LSIL (21.5%), ASC in 28 cases (19.4%), and HSIL in 6 cases (4.2%), and found that women with HPV typing Type Non 16/18 and having an age range of 50-59 years have the most NILM test results (46.8 %), while those aged 40-49 years have the most test results in the >ASC-US group (44.6%), which is a significant difference. Statistically significant (P-value = 0.048).  The HPV Non 16/18 are not related to the Liquid Base Cytology test results (P-value = 0.048)

Conclusion:  HPV DNA Test results as Type Non 16/18 are not related to the Liquid Base Cytology test results in Thai women who went for cervical cancer screening. However cervical cancer screening should be promoted to high-risk groups. Focusing on all high-risk HPV Types Non 16/18. Moreover, using such information to manage the health system in order to reduce the risks of the disease as well as increase the chance of treatment in the early stages. Consequently, the treatment will be effective. This is an important step in increasing quality of life and effectively reducing the burden of medical expenses on society.