Sensitivity and Specificity of Colposcopy Directed Biopsy for the Diagnosis of High Grade Lesions Retrospective Study at Vachira Phuket Hospital
Keywords:
Colposcopy directed biopsy, high-grade lesion, Sensitivity, SpecificityAbstract
Background: Colposcopy is a standard for the early diagnosis of cervical intraepithelial neoplasia (CIN) and to plan treatment.1 The accuracy of colposcopy varies in different reports depending on experience. A 2023 meta-analysis study reported sensitivity of 68 percent and specificity of 93 percent.
Objectives: To produce descriptive statistics for sensitivity and specificity of colposcopy directed biopsy (CDB) and colposcopy impression (CI) compared with final pathological diagnosis.
Method: Data was retrospectively collected from January 2019 to July 2021. CI reports and pathological reports of CDB were compared with a final pathological diagnosis from either the loop electric excision procedure (LEEP) or hysterectomy.
Results: 264 patients underwent a colposcopy procedure during this study. 90 patients underwent LEEP only 66 patients who reported adequate colposcopy were included in the study. CDB for detected high-grade lesions (HGL) had 83.3 percent sensitivity and 91.6 percent specificity. Colposcope impression had 75 percent sensitivity and 74 percent specificity.
Conclusion: CDB for the diagnosis of HGL has high sensitivity and specificity. Multiple biopsy procedures should be undertaken to improve accuracy.
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