Antibody Response to Coronavirus Disease 2019 (COVID-19) Vaccination in Pregnant Women and Transplacental Passage Into Cord Blood in Phuket, Thailand
คำสำคัญ:
SAR-CoV-2 Vaccine, Pregnancy, Cord blood, Correlationบทคัดย่อ
Background: Pregnant women are a vulnerable group for Covid-19 infection. The rates of pregnancy and neonatal adverse outcomes, such as mortality, hospital admission, intensive unit care admission, intubation, preeclampsia, abortion, low birth weight, preterm birth, neonatal intensive care unit admission, neonatal sepsis, neonatal death, and vertical transmission, have increased. Many health organizations encourage vaccination during pregnancy due to the safety and efficacy of vaccines in pregnant and lactating women. Infant neonatal immune responses from the mother are important. Many studies have found a good correlation between maternal serum and cord blood antibody levels. However, vaccination during pregnancy had very low coverage, especially in 2023, when COVID-19 became an epidemic infection. In Thailand, various types of Covid-19 vaccines were used, such as Sinovac, AstraZeneca, and mRNA vaccines (Pfizer and Moderna), with some individuals receiving mixed types.
Objectives: This study was designed to estimate the correlation of antibodies in pregnant women and cord blood among Thai pregnant women who received at least one dose of any Covid-19 vaccine both before and during pregnancy.
Methods: Between October 25 and November 9, 2023, the Labor Room of Vachira Phuket Hospital recruited forty low-risk pregnancies with a history of receiving at least one Covid-19 vaccine. We collected demographic data, maternal blood, and cord blood. COVID-19 Spike Protein IgG Quantitative Antibody (Alinity I SAR-CoV-2 IgG II Quant) was tested. Correlations and neonatal outcomes were analyzed.
Results: According to this study, the median of maternal serum SARS-CoV-2 IgG was 2805.00 (535.2, 43212.70) AU/mL, and the median of cord blood SARS-CoV-2 IgG was 4098.00 (479.30, 35085.30) AU/mL. The cord blood and maternal serum SARS-CoV-2 IgG levels at delivery were strongly positively correlated (R = 0.953, P < 0.0001).
Conclusion: The cord blood and maternal serum SARS-CoV-2 IgG levels at delivery were strongly positively correlated.
เอกสารอ้างอิง
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