Comparison for Efficacy in Postoperative Pain Relief in Major Gynecologic Surgery of Buprenorphine and Meperidine

Abstract

Comparison for Efficacy in Postoperative Pain Relief in Major Gynecologic Surgery of Buprenorphine and Meperidine

Chullasak      Sroiwatana        MD

Manit              Sripramot          MD

Siriwan           Tungjitkamon   MD

Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital

Objective: To compare the efficacy of sublingual buprenorphine versus intravenous meperidine in major gynecologic surgery.

Study design: Gynecology ward, Department of Obstetrics and Gynecology, BMA Medical College and Vajira Hospital.

Subjects: Sixty six patients who were operated for gynecologic condition between  June 1999 and May 2000.

Methods: All 66 patients were divided into 2 groups by random allocation.  Group 1 (n=33) were received sublingual buprenorphine 0.4 mg due to pain after the surgery.  Group 2 (n=33) were received intravenous meperidine 1mg/kg due to pain after the surgery.  Pre and post operative pain score were evaluated by visual analogue scale (VAS).

Main outcome measures: Mean pain relief of both groups.

Results: The mean pain relief at 4 hour post operation in the buprenorphine group was statistically significant higer than the meperidine group, 8.1+1.93 and 3.8+3.44 respectively (95% CI 3.0 to 5.7, p < 0.001).  The number of patients requiring second dose in buprenorphine group was less than of meperidine group (4(12.1%) and 18(54.5%), respectively) which was statistically significant difference (p = 0.001).  The side effects between the two groups were no statistically significant difference (p > 0.05).

Conclusion: Sublingual buprenorphine was better than meperidine in postoperative pain relief in major gynecologic surgery.

Key words: buprenorphine, meperidine, postoperative pain

Vajira Med J 2001 ; 45 : 83 - 91