Troponin I as a Cardiac Marker

Abstract

Troponin I as a Cardiac Marker

Pacharin        Rugdech        BSc(Medical technology), MSc (Microbiology)

Department of Central laboratory, BMA Medical College and Vajira Hospital

Objective: To study troponin I in the term of cardiac marker by comparing with other cardiac enzymes (AST, LDH. CK and CK-MB).

Study design: Diagnostic test.

Subjects: Three groups of samples were collected from patients at BMA Medical College and Vajira Hospital, 15 diagnosed AMI, 20 healthy blood donor subjects, and 6 other various patients from medical ICU.

Methods: All samples were analysed for cardiac enzymes (AST, LDH, CK, CK-MB) by automatic chemical machine except for troponin I by automatic immunological machine.

Main outcome measures: Specificity, sensitivity and accuracy of troponin I and other cardiac enzymes in the term of cardiac markers.

Results: It was found that all 15 AMI samples have positive troponin I (100% specificity, 100% sensitivity and 100% accuracy) and was not found in other groups.  Whereas AST, LDH, CK, CK-MB were 88.5%, 96.2%, 96.2% 100% specificity, 73.3%, 60%, 80%, 73.3%sinsitivity and 82.9%, 82.9%, 90.2%, 90.2% accuracy respectively.

Conclusion: Troponin I was the most reliable cardiac marker for diagnosis of AMI comparison with other enzymes.

Key words: thoponin I, cardiac enzymes, cardiac marker

Vajira Med J 2001 ; 45 : 145 - 149