Rare Types of Amyloidosis and their Pathogenesis: Targets for Innovative Therapy

Abstract

Amyloidosis light chain (AL) which is caused by abnormal immunoglobulin storage with idiopathic feature oris precipitated by B cell or plasma cell tumors often occurs throughout the body as the most frequent type ofamyloidosis. There are also other kinds which are the result of genetic disorders or other acquired abnormalities suchas infections, chronic inflammation, or other tumors. These disorders may cause abnormal storage at limited siteswhich may be handled with local treatment. However, the storage sites may also be distributed through systemicinvolvement. Chemotherapy or other therapies have not been successful in the treatment of these types. Prevention ofcomplications from the disease is an important issue of concern. Studying the mechanisms of the disease leads toinnovations that can be used in targeted therapy which may be more effective in reducing the accumulation ofabnormal proteins.