The Anti-staphylococcal Property of Mold-made Kanamycin-impregnated Polyme­thylmethacrylate Beads Compared with Septopal®

Abstract

The Anti-staphylococcal Property of Mold-made Kanamycin-impregnated Polyme­thylmethacrylate Beads Compared with Septopal^®

Damrong Thapanakulsak MD

Chiroj         Soorapanth MD

Department of Orthopaedic Surgery, BMA Medical College and Vajira Hospital

Objective : To Compare the anti-staphylococcal property by agar diffusion method of mold-made kanamycin­impregnated polymethylmethacrylate beads and Septopal®

Study design : Experimental study.

Setting : The Department of Orthopaedic Surgery and Department of Pathology, BMA Medical College and Vajira Hospital, during September 1999 - February 2000.

Subjects : Thirty beads of Septopal® and 30 beads of mold-made kanamycin-impregnated polymethylmethacrylate (PMMA).

Methods: The thirty beads of kanamycin - impregnated PMMA were mold -made in operating suite with aseptic technique and studied for anti- staphylococcal property by agar diffusion method comparing to so beads of Septopal® for 7 days.

Main outcome measures : The zones of inhibition of Septopal® and mold-made kanamycin-impregnated PMMA.

Results : The zones of inhibition of both groups were significantly more than the zone diameter interpretive standards (Z > 3.08, 0.002). The zones of inhibition of Septopal® were significantly more than mold-made kanamycin-­impregnated PMMA (Z > 3.08, 0.002).

Conclusion: Both Septopal® and kanamycin-impregnated PMMA beads significantly inhibited the growth of S aureus. The antimicrobial activity of Septopal® was higher with statistically significant difference. The kanamycin-impregnated bead was an alternative when Septopal® and gentamicin powder were not available.

Key words : antibacterial property, mold-made kanamycin-impregnated PMMA bead, Septopal®

Vajira Med J 2001 ; 45 : 217 - 222