Incidence of Red Cell Alloantibodies

Abstract

Incidence of Red Cell Alloantibodies

Nutthinee           Archavarungson              BSc (Med Tech), MSc (Med Tech)

Department of Blood Bank, BMA Medical College and Vajira Hospital

Objective : To study the incidence of red cell alloantibodies from patients' blood in BMA Medical college and Vajira Hospital.

Study design : Descriptive study.

Subjects : A total of 1,095 sera from the patients in BMA Medical college and Vajira Hospital had been studied during January 1996 to December 2000. These sera were positive results from antibody screening test.

Methods : The retrospective study for the incidence of red cell alloantibodies were performed. Antiboby identification datas, both type and amount of alloantibodies, were collected and compared together.

Main outcome measures : The incidence of red cell alloantibodies in patients' blood.

Results : The incidence of red cell alloantibodies was 2.2-3.9%. One immunizes antibody was found 92 -155 cases (58.5 - 67.2). Two immunized antibodies were found 15 - 31 cases (7.1 - 12.7%). Three immunized antibodies were found 0 -2 cases (0-0.8%). Four immunized antibodies which were found only one case in 1996 (0.7%). Autoimmune antibody and unidentify antibody were 5-13cases (2.5-5.5%) and 23-68 cases (16.8-25.7 %), respectively. From one immunized antibody datas, it revealed that anti- Le^a, anti-Mi^a, anti - Le^a+b, anti- Le^b, anti-E and anti-P were often found. They were 12-38 cases (8.8-16.2%), 20-53 cases (14.6-20%), 24-54 cases (10.2-22%), 6-17 cases (2.6-8.0%), 6-17 cases (4.1-7.2%) and 10-23 cases (3.8-9.4%), respectively. The others bas the same results as one immunized antibody.

Conclusion : The incidence of red cell alloantibodies was 2.2 - 3.9 %. From this study, the most red call alloantibodies, which was often found in patients' blood in BMA Medical college and Vajira hospital, were anti - Le^a, anti-Mi^a, anti- Le^a+b, anti- Le^b, anti-E and anti-P.

Key words : red cell alloantibodies, antiboby identification datas, immunized antibody

Vajira Med J 2002 ; 46 : 51 - 57