A Comparative Study of 2.5% Acetic acid and Ofloxacin Ear Drop for Treatment of Acute Otitis Externa
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Abstract
Objective:To compare outcome of treatment of acute otitis externa between 2.5% acetic acid and ofloxacin ear drop
Methods:This study is a randomized controlled trial. In acetic acid group, 5% acetic acid from the market was diluted 1:1 with drinking water to 2.5% acetic acid. In ofloxacin ear drop group, 0.3% Tarivid® otic solution was used. Patients in both groups used same process of using antibiotic ear drop and were followed up for pain score, discharge in ear and ear canal swelling at 7, 14 and 21 days after treatment.
Results:108 patients received 2.5% acetic acid and 109 patients received ofloxacin ear drop. Mean age was 43.6 years. Female were more common than male. Cure rate at 7,14 and 21 days of ofloxacin ear drop group were 88.07%, 93.58% and 93.58% consecutively and those of acetic acid group were 89.94%, 94.47% and 95.40%, consecutively.There were no statistically significant difference of cure rate between groups. 79 patients (67.52%), comprised 14 patients (12.73%) from ofloxacin group and 65 patients (59.1%) from acetic acid group, had burning sensation in ear canal in the first 3 day of use. No patient had burning sensation after 7 days.
Conclusion:2.5% Acetic acid and ofloxacin ear drop had similar efficacy for treatment of acute otitis externa. But 2.5% Acetic acid caused more burning sensation in the first 3 days
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References
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