Outcome of Newborn’s Gestational Age at 34-36 Weeks Whose Mothers were Diagnosed with Premature Rupture of Membranes: Comparison between Induction and Expectant Management
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Abstract
Objectives: To compare neonatal outcomes of preterm newborns of with a gestational age of 34 -36 week, whose mothers were diagnosed with premature rupture of membranes between the induction of labor and the expectant management group. Primary outcome was neonatal sepsis.
Methods: This was a retrospective study. The data were collected from preterm newborns of gestational age 34 -36 weeks, whose mothers were diagnosed with premature rupture of membranes at Vajira Hospital from 1st January 2011 to 31th December 2015
Results: 189 newborns were included in this study. There were 89 newborns in the induction management group and 100 newborns in the expectant management group. The reference group was the expectant management group. Neonatal sepsis was seen in 27% in the induction management group versus 61% in expectant management group. (Odds ratio 0.45, 95%CI 0.31-0.65, p-value <0.001) In addition, newborns in the expectant group had significant lower birth weight and lower median gestational age than newborns in induction groups. However, multivariate analysis, which adjusted for factors associated with neonatal sepsis, showed no significance between the two groups in primary and secondary outcomes.
Conclusion: Expectant management in case of newborns whose mothers were diagnosed with premature rupture of membranes at gestational age 34-36 weeks were more affected by neonatal sepsis than the induction management group. Due to the results of this study, newborns in the expectant group had lower birth weight and lower median gestational age than newborns in induction groups. The results of this study can be used to improve quality of care and raise awareness of preterm PROM in expectant management.
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References
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