Postoperative Pain and Healing of Tonsillectomy Wound Using Topical Sucralfate

Main Article Content

Girapong Ungkhara
Sirinan Junthong
Patcharin Bunnag

Abstract

Objective: Tonsillectomy is a common operative procedure performed for many tonsillar diseases. Among post tonsillectomy morbidities, delayed wound healing, postoperative pain and bleeding are the most important complications. The objective of this study was to evaluate the effect of sucralfate on postoperative pain and wound healing after tonsillectomy.


Methods: A prospective randomized double-blind study was performed on 36 consecutive patients undergoing tonsillectomy. Sixteen were male, 20 were female, with the mean age of 29.78 ± 11.04 years. All patients were randomly assigned to treatment with ground sucralfate tablet (1 gram) dissolved in 1 ml normal saline solution to make a paste applied to one tonsillar fossa after procedure perioperatively. Pain score was assessed daily from day 0 to day 7 and mucosal coverage was assessed at day 7 postoperatively. Data of both experimental and controlled conditions were recorded and statistically analyzed. Differences between groups in mucosal coverage and pain score were evaluated with paired T-test.


Result: Mucosal coverage was significantly faster in the treatment group for both tonsillar fossae compared to the control group (p = 0.033) with no significant difference in pain score at day 0 to day 7 postoperatively (p > 0.05).


Conclusion: Ground sucralfate tablet has a positive effect in enhancing the healing process in post tonsillectomy wounds. It is easy to use topically, safe, and available locally at low cost. It can be used as an adjunct therapy for post-tonsillectomy patients.

Article Details

How to Cite
Ungkhara, G., Junthong, S., & Bunnag, P. (2017). Postoperative Pain and Healing of Tonsillectomy Wound Using Topical Sucralfate. Vajira Medical Journal : Journal of Urban Medicine, 61(4), 257–266. Retrieved from https://he02.tci-thaijo.org/index.php/VMED/article/view/196096
Section
Original Articles

References

1. Stephen BF, Kevin M. Sucralfate in alleviating post-tonsillectomy pain. Laryngoscope. 1992;102: 1242-6.

2. Pichai P. A radomized study of postoperative pain comparing between coblation and electrosurgical tonsillectomy. Vajira Med J. 2010; 54:3-8.

3. Lise M, Frank M. No clinical advantages of coblation tonsillectomy compared with traditional tonsillectomy. Danish Med J. 2012;59(1):1-5.

4. Diakos EA, Gallos ID, El SS, Clarke M., Kazi, R., Mehanna, H. Dexamethasone reduces pain, vomiting and overall complications following tonsillectomy in adults: a systematic review and meta-analysis of randomized controlled trials. Clin Otolaryngol. 2011; 36:531–42.

5. Saeed K, Fariborz G, Hamid RH. Intravenous and peritonsillar infiltration of ketamine for postoperative pain after adenotonsillectomy: A randomized placebo-controlled clinical trial. Med Princ Pract. 2011; 20:433–7.

6. Thorburn K, Samuel M, Smith EA, et al. Aluminum accumulation in critically ill children on sucralfate therapy. Pediatr Crit Care Med. 2001;2:247-9.

7. Banati A, Chowdhury SR, Mazumder S. Topical use of Sucralfate Cream in second and third degree burns. Burns. 2001; 27: 465–9.

8. Pravin JG, Purushottam SH, Subhash AS, Surekha SK. Topical Sucralfate Treatment of Anal Fistulotomy Wounds: A Randomized Placebo-Controlled Trial, Dis Colon Rectum. 2011; 54: 699–704.

9. Gul YA, Prasannan S, Jabar FM, et al. Pharmacotherapy for chronic hemorrhagic radiation proctitis. World J Surg. 2002;26:1499-502.

10. Pin L, George L. Disease recommendation for clinical management of mucocutaneous lesions. J Clin Rheumatol. 2006; 12:282-6.

11. Erkan A, Hanief ER, Cicek D, Ertan Y. The use of sucralfate suspension in the treatment of oral and genital ulceration in Behcet disease : A randomized, placebo-controlled, double-blind study. Arch Dermatol. 1999;135: 529-32.

12. Bertram G. Katzung Basic and Clinical Pharmacology 10th edition. New York, NY: McGraw-Hill Medical; 2006.

13. Brunton L, Chabner BA, Knollman B. Goodman & Gilman’s. The Pharmacological basis of therapeutics 12th edition. New York, NY: McGraw-Hill Education; 2011.

14. Zodpe P, Cho JG, Kang HJ, Hwang SJ, Lee HM. Efficacy of sucralfate in the postoperative management of uvulopalatopharyngoplasty: a double-blind, randomized, controlled study. Arch Otolaryngol Head Neck Surg. 2006;132:1082–5.

15. Markham T, Kennedy F, Collins P. Topical sucralfate for erosive irritant diaper dermatitis. Arch Dermatol. 2000; 136:1199–200.

16. Nagashima R. Mechanisms of action of sucralfate. J Clin Gastroenterol. 1981; 3:117–27.

17. Samloff IM. Inhibition of peptic aggression by sucralfate: the view from the ulcer crater. Scand J Gastroenterol Suppl. 1983; 83:7–11.

18. Rees WD. Mechanisms of gastroduodenal protection by sucralfate. Am J Med. 1991; 91:58S– 63S.

19. Crampton JR, Gibbons LC, Rees W. Effects of sucralfate on gastroduodenal bicarbonate secretion and prostaglandin E2 metabolism. Am J Med. 1987; 83:14–8.

20. Chau-Shiang G, Hui-Ching C, Chih-Yen C. Topical sucralfate for pain after oral CO2 laser surgery: a prospective, randomized, controlled trial. Am J Otol Head Neck Med Surg. 2012; 33:109–12.

21. Kyrmizakis DE, Papadakis CE, Bizakis JG, et al. Sucralfate alleviating post–laser-assisted uvulopalatoplasty pain. Am J Otolaryngol.2001; 22: 55-8.

22. Zodpe P, Cho JG, Kang HJ. Efficacy of sucralfate in the postoperative management of uvulopalatopharyngoplasty: a doubleblind, randomized, controlled study. Arch Otolaryngol Head Neck Surg. 2006;132: 1082-5.

23. Miura MS, Saleh C, de Andrade M, et al. Topical sucralfate in postadenotonsillectomy analgesia in children: a double-blind randomized clinical trial. Otolaryngol Head Neck Surg. 2009;141: 322-8.

24. Sandor Z, Nagata M, Kusstatscher S, Szabo S. Stimulation of mucosal glutathione and angiogenesis: new mechanisms of gastroprotection and ulcer healing by sucralfate. Scand J Gastroenterol Suppl. 1995;210:19 –21.

25. Tryba M, Mantey-Stiers F. Antibacterial activity of sucralfate in human gastric juice. Am J Med. 1987; 83:125-7.

26. Bruce HM, Bryan J K, Yan D, Beth EJ. Effect of tonsillar fossa closure on postoperative pain and bleeding risk after tonsillectomy. Int J Ped Otorhinolaryngol. 2012;76: 1799–1805.

27. Nili S , Moshe P ,Eran R. A prospective randomized double-blind trial of fibrin glue for reducing pain and bleeding after tonsillectomy. Int J Ped Otorhinolaryngol. 2008; 72(4): 469-73.

28. Norhafiza ML, Baharudin A, Rosdan S. The effect of Tualang honey in enhancing post tonsillectomy healing process. An open labelled prospective clinical trial. Int J Ped Otorhinolaryngol. 2013;77: 457–61.

29. Isaacson G. Tonsillectomy Healing; Ann Otol Rhinol Laryngol 2012; 121: 645-9.

30. Temir ZG, Karkiner A, Karaca I, Ortaç R, Ozdamar A. The effectiveness of sucralfate against stricture formation in experimental corrosive esophageal burns. Surg Today. 2005;35(8):617-22.