Comparative Study of Blood Electrolyte between Two Automated Chemistry Analyzers; Ciba Corning FAST4 and Cobas INTERA400

Abstract

Comparative Study of Blood Electrolyte between Two Automated Chemistry Analyzers; Ciba Corning FAST4 and Cobas INTERA400

Lamul    Wongkritwit    BSc (Med-Tech)

Department of central Laboratory, BMA Medical College and Vajira Hospital

Objective: To compare blood electrolyte measured by direct ion selective electrode (direct ISE) from FAST4 Analyzer and indirect ion selective electrode (indirect ISE) from INTERA 400 Analyzer.

Study design: Cross-sectional analytic study.

Subjects: One hundred and twenty blood samples were collected from patients requested for electrolyte determination at Department of Central Laboratory, BMA Medical College and Vajira Hospital during March 17-31, 2003

Methods: One hundred and twenty blood samples were determined for electrolyte by direct ISE from FAST4 Analyzer and indirect ISE from INTERA 400 Analyzer.  The data from two methods were compared and analyzed for statistical correlation.

Main outcome measures: The amounts of sodium, potassium, chloride and carbon dioxide from two methods were compared and analyted for statistical correlation.

Results: Data from the two methods were statistically calculated.  The correlation studies of all parameters including sodium, potassium, chloride and carbon dioxide showed good correlation.  The correlation coefficient (r) were 0.9558, 0.9785, 0.9618 and 0.9662 and linear regression were Y(IN400)=1.1X+11, Y(IN400) = X - 0.07, Y(IN400) = 0.97X+7.75 and Y(IN400) = 1.02X + 3.4, respectively. Sodium, chloride and carbon dioxide showed statistical significant differences (p < 0.05) but potassium showed no statistical significant differences (p > 0.05)

Conclusion: Statistical analysis showed that The FAST4 Analyzer and The INTERA 400 Analyzer were strongly correlated but slop and intercept of sodium, chloride and carbon dioxide in parameter of The INTERA 400 Analyzer should adjust by linear regression equation except potassium that showed no significant statistical differences (P > 0.05)

Key word: blood electrolyte, directy, indirect, automated chemistry analyzer

Vajira Med J 2003 ; 47 : 133 - 137