Prevalence of Thalassemia and Hemoglobinopathyin the Users of Thalassemia Screening Service at Queen Savang Vadhana Memorial Hospital, The Thai Red Cross Society

Abstract

Objective: of the descriptive research is to study prevalence of Thalassemia and Hemoglobinopathy in the users of Thalassemia screening service at Queen Savang Vadhana Memorial Hospital.

Methods: The Thai Red Cross Society. InThalassemia and Hemoglobinopathy screening, CBC, OF, DCIP, and α-thalassemia IC strip test were used to examine and separate for analysis of types of Hemoglobin with Cellulose acetate electrophoresis and HPLC The size of samples was calculated from prevalence of the latest research where prevalence of Thalassemia in the users of Thalassemia screening service was detected in the rate of 35.89% using formula of n = z2 ' p ' ´(1-p)/d 2. At least 181 persons were acquired as the size of samples. The sample group in this research was all users of Thalassemiascreeningservicein 2016.

Results: The finding of studying results Prevalence of thalassemia carriers Hemoglobin E, 29.2% and EE homocysts, hemoglobin E 23, 3.9%, hemoglobin carriers, EE / EF, 2.2% and alpha-thalassemia carriers 0.2 . The finding from screening of -thalassemia carrier with -thalassemia IC strip test indicated positive results for 63.2%. Hb typing was conducted with Cellulose acetate electrophoresis Method and confirmed with HPLC Method. In suspicious cases, the finding indicated abnormal results or being Thalassemia diseased for 38.8% consisting of Betathalassemiadiseased for 35.2% and Alpha-thalassemia for 3.6%.

Conclusion : Prevalence of thalassemia And hemoglobin disorders by screening. CBC, OF, DCIP, - thalassemia IC strip test and hemoglobin assay using cellulose acetate electrophoresis and HPLC to guide volunteers. Thalassemia carriers were counseled to plan their family and reduce the incidence of thalassemia in the future.