Prosperity of celecoxib for pain relief after elective cesarean delivery, a double-blind randomized controlled trial

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Published: Jun 30, 2020
DOI: https://doi.org/10.14456/vmj.2020.16
Keywords:
elective cesarean delivery post-operative pain celecoxib effectiveness

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Thunwipa Tuscharoenporn
Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
Pahsuvudn Kongsin
Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
Busaba Supawatttanabodee
Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand
Piyasak Vitayaburananont
Department of Anesthesiology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand

Abstract

Objective: To determine the effectiveness of 400-mg celecoxib after elective cesarean delivery.


Methods: In this randomized double blinded controlled trial, 110 full-term pregnant women aged between 20-40 years old who were scheduled for elective cesarean delivery between May 2018 and November 2018 were enrolled. A total of 110 participants were randomly assigned equally into 2 groups to receive celecoxib or placebo. All patients from both groups received meperidine under PCA after operation. Pain score was measured 3 times with 2 different states: 6, 12 and 24 hour at rest and upon movement.


Results: The overall pain score in each time point between PCA meperidine plus celecoxib and PCA meperidine plus placebo was significantly different (p-value = 0.004). The use of meperidine at 24 hours in the group of PCA meperidine plus celecoxib was not significantly different from the group of PCA meperidine plus placebo (p-value =0.058)


Conclusion: Celecoxib could relieve post-operative pain after cesarean delivery statistic significantly.

Article Details

How to Cite
Tuscharoenporn, T., Kongsin, P., Supawatttanabodee, B., & Vitayaburananont, P. (2020). Prosperity of celecoxib for pain relief after elective cesarean delivery, a double-blind randomized controlled trial. Vajira Medical Journal : Journal of Urban Medicine, 64(3), 165–172. https://doi.org/10.14456/vmj.2020.16
Issue
Vol. 64 No. 3 (2020): MAY - JUN 2020
Section
Original Articles

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