Prosperity of celecoxib for pain relief after elective cesarean delivery, a double-blind randomized controlled trial
Keywords:elective cesarean delivery, post-operative pain, celecoxib, effectiveness
Objective: To determine the effectiveness of 400-mg celecoxib after elective cesarean delivery.
Methods: In this randomized double blinded controlled trial, 110 full-term pregnant women aged between 20-40 years old who were scheduled for elective cesarean delivery between May 2018 and November 2018 were enrolled. A total of 110 participants were randomly assigned equally into 2 groups to receive celecoxib or placebo. All patients from both groups received meperidine under PCA after operation. Pain score was measured 3 times with 2 different states: 6, 12 and 24 hour at rest and upon movement.
Results: The overall pain score in each time point between PCA meperidine plus celecoxib and PCA meperidine plus placebo was significantly different (p-value = 0.004). The use of meperidine at 24 hours in the group of PCA meperidine plus celecoxib was not significantly different from the group of PCA meperidine plus placebo (p-value =0.058)
Conclusion: Celecoxib could relieve post-operative pain after cesarean delivery statistic significantly.
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