Comparison of Thyrotropin Human Serum by Immulite Immunochemilu minometric Assay (iICMA) and Ria-gnost Immunoradiometric Assay (rIRMA).
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Abstract
Comparison of Thyrotropin Human Serum by Immulite Immunochemilu minometric Assay (iICMA) and Ria-gnost Immunoradiometric Assay (rIRMA).
Chanteema Sanyanusin, BSc (Med-Tech)
Department of Radiology BMA Medical College and Vajira Hospital
Objective: To compare Thyrotropin in human serum by lmmulite immunochemiluminometric assay (iICMA) and Ria-gnost immunoradiometric assay (rIRMA)
Study design: Cross-sectional analytic study
Subjects: One hundred and twenty blood samples were collected from patients with suspected thyroid disorders and treated at BMA Medical College and Vajira Hospital from December 2002 to March 2003. Methods: One hundred and twenty blood samples were determined for Thyrotropin by Immulite immunochemiluminometric assay and Ria-gnost immunoradwiometric assay. The data from two methods were compared and analysed for the statistical evaluation by linear regression and student paired t-test.
Main outcome measures: Serum Thyrotropin from two methods were analysed for the method comparison studies.
Results: The comparison between the iICMA and rIRMA for TSH showed a good correlation between the two methods. The regression analysis of this correlation study gave a correlation coefficient (r) of 0.983. Both methods showed statistically significant differences (p < 0.05)
Conclusion: Statistical analysis showed that the determination of Thyrotropin by Immulite immunochemilumi-nometric assay (iICMA) and Ria-gnost immunoradiometric assay (rIRMA) had a good correlation. So lmmulite immunochemiluminometric assay (iICMA) can be used to used to replace Ria-gnost immunoradiometric assay (rIRMA).
Key words: Thyrotropin, immunochemiluminometric assay, immunoradiometric assay.
Vajira Med J 2004 ; 48 : 27 - 31