Incidence of Patent Ductus Arteriosus that Related to Successful Indomethacin Treatment in TAKSIN HOSPITAL

Abstract

Incidence of Patent Ductus Arteriosus that Related to Successful Indomethacin Treatment in TAKSIN HOSPITAL

Gunthaporn  Surabenchawong  MD

Department of Pediatric, Taksin Hospital

Objective: To study the incidence of PDA in premature infants which definite diagnosis by clinical symptoms.

2D and doppler echocardiography compare with all premature infants in Taksin Hospital and factors that

related to successful indomethacin treatment.

Study design: Retrospective study.

Setting: Department of Pediatric, Taksin Hospital.

Subjects: 53 premature infants with PDA from October 1998 to September 2002

Methods: Data on gestational age, birth weight, sex, day of opened PDA, status of infection, respiratory equipment. complication of patients, PDA closed/non-closed/reopened after indomethacin treatment in premature infants  with PDA, all premature infants, were reviewed and collected and analyzed.

Main outcome measures: The amount and percent of premature infants with PDA that closed/non-closed/ reopened after indomethacin treatment, and factors that related to successful indomethacin treatment.

Results: Incidence of PDA in premature infants in Taksin Hospital was 2.65%. 11 patients were excluded because of spontaneous closure in 8 patients and contraindication for indomethacin treatment in 3 patients. 37 in 42 patients (88%) were closed by the first course of indomethacin treatment and reopened IO in 37 patients (29%). When compared two groups between closed and non-closed/reopened groups for looking for the factors that related to successful indomethacin treatment, the study found that infection (lungs infection

and septicemia) was significant difference (p=0.019) but gestational age, birth weight. sex, day of opened

PDA, equipment for treatment respiratory problems, route for indomethacin treatment were not significant

difference (p=0.157, p=0.531, p=0.495, p=0.487, p=0.199. p=U.531 respectively). For complications like NEC. CLD and death were no significant difference too (p=0.638, p=0.114, p=0.713 respectively).

Conclusion: Incidence of PDA in premature infants in Taksin Hospital was low. Successfully indomethacin

treatment was not different from the other studies. The complications were low too. Influence factor that

make non-closed/reopened PDA was infection especially lung's infection.

Keys words: Patent ductus arteriosus, premature infants, indomethacin.

Vajira Med J 2004 ; 48 : 67 - 78