Prevalence of Androgen Receptor Expression in Breast Cancer Patients in Charoenkrung Pracharak Hospital

Abstract

Objectives: To study the prevalence of androgen hormone receptor and factors that affect expression of the androgen receptor in Thai female breast cancer patients.

Methods: Prospective descriptive study was performed by enrolled female breast cancer patients, whose age above 18 years, in Charoenkrung Pracharak Hospital between 1 October 2011 and 1 October 2013. The detection of androgen receptor by immunohistochemistry study of the breast cancer specimens was done. The results were reported as the prevalence of androgen hormone receptor and the factors affecting the expression of androgen hormone receptor.

Results: Total 54 patients were enrolled in this study. The mean age was 50.3±11.0 years old. Out of 54 cases, 44 cases (83.3%) had androgen receptor positive. Age, weight, height, BMI, clinical pathology and menstrual status of the patient had no effect on the expression of androgen receptor. The study found that the expression of estrogen receptor and histology of triple negative breast cancer affected on the expression of androgen receptor in Thai breast cancer patients.

Conclusion: The prevalence of androgen receptor in Thai breast cancer patients was 83.3%. The factors affected the expression of androgen were the level of estrogen receptor. While triple negative breast cancer had less expression of androgen receptor.