Survival Analysis after Surgery of Colorectal Cancer in Vajira Hospital

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Punnawat Chandrachamnong

Abstract

Background: Colorectal cancer (CRC) is the third most common cancer diagnosed in men and the second most common in women from global cancer statistics1. In 2014, there were an estimated 1,317,427 people living with colon and rectum cancer in worldwide. Approximately 4.3 percent of people will be diagnosed with colon and rectum cancer during their lifetime. However colorectal cancer is one of the cancers that can be prevented by secondary prevention and it can be cured by the detection at earlier stage and early removal tumor. In the past of Thailand, colorectal cancer mostly founded after their complications such as obstruction, perforation or bleeding2 resulting in poorer operative outcome and shorter survival rate than western country. Objective: The aim of this study was to evaluate the incidence of colorectal cancer survival rate within 5 years after surgery, 5 years disease free survival rate and risk factors associated survival outcome in Vajira hospital.


Methods: A retrospective study on 5 year-over all survival rate of patients who underwent major surgical procedure of CRC in Colorectal surgery unit, Department of surgery, Faculty of Medicine Vajira Hospital between January 2010 - December 2011 were reviewed. Overall survival and disease free survival rate of colorectal cancer within 5 years after operation and their risk factors were evaluated. P value less than 0.05 were considered significant. All analysis was done using SPSS software.


Results: A total 185 patients underwent resection of CRC during the study period 111 patients were enrolled, with mean age of 73 ± 19 years. Sixty-six patients (59.5%) were diagnosed with colon cancer and 45 patients (40.5%) were diagnosed with rectal cancer. Stage III colorectal cancer was the most common stage : 57 patients (51.3%). Five year-overall survival rate of 72% (stage I : 89% ,stage II : 80% , stage III : 59%) and median survival time of 84 month. Five year disease free survival rate of 68% (stage I : 89% ,stage II : 75% , stage III : 57%). N Staging was prognosis factors of disease free survival.


Conclusion: The 5 year-over all survival rate was 72% and median survival time was 84 months. The 5 year-disease free survival rate was 68%. The prognostic factors of disease free survival were associated with N staging.

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References

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